In 2016, one study explored the ability to detect polio cases in populations with high IPV coverage, which highlighted that asymptomatic infections may mask live poliovirus transmission and suggested longer delays to detection as vaccine coverage and/or the proportion of the population with only IPV vaccination increases [210]. Revisiting a simple theoretical model of silent circulation developed in the mid-1990s [197] and reconsidered by KRI in 2012 [27], a 2016 analysis emphasized further limitations of the simple model with respect to consideration of the vaccination history [161]. Modeling the experience with WPV1 reintroduction into Israel, one study used a DEB model to characterize the importance of using OPV to interrupt WPV transmission in a developed country with very high IPV coverage [162]. A theoretical DEB model highlights OPV as an example of a weakly transmissible vaccine for which the transmissibility of the vaccine can help with global eradication efforts [211].