Sample VI
Histomorphological analysis shows peribronchial alveolar parenchyma with lymphocytic interstitial pneumonitis and a singular thrombus in a small vein. The interstitium of the alveolar septae is widened by myogenic metaplasia. Adjacent, centrilobular emphysema and anthracosis are observed. The bronchial mucosa shows varying degrees of lymphocytic inflammation in the sense of chronic bronchitis/bronchiolitis (original magnification 100×). From PC-CT reconstructions, the sample consists of thin alveoli (Figure 3VI, upper left) evolving into compact, fibrotic tissue (Figure 3VI, lower right). The amount of lymphocytes is rather low in this sample. Black granules and some thrombi are embedded within the bulky tissue parts. The biopsy punch covers the region of transition from alveoli to fibrotic tissue, containing also a thrombus and capillaries as identified from the zoom tomogram.