As mentioned previously, epidemiological data from many countries report that children make up a small minority of those who test positive. Children account for 1–5% of patients and are less likely to become severely ill compared with adults, though preschool children and infants might have severe clinical features [95,96]. The small rate of COVID-19 infection for children has also been confirmed by another study which showed that children younger than 18 years made up less than 2% of national cases in different countries [97], so that, also in this case, that proportion reflects lower susceptibility among children versus adults [98]. The emergence of a severe Kawasaki-like disease in children related to COVID-19 has now shifted focus on the vulnerability of children [99]. It is a rare acute pediatric vasculitis, with the development of coronary artery aneurysms as its main complication. Diagnosis of this disease is based on the presence of persistent fever, lymphadenopathy, conjunctival injection exanthema and changes to the mucosae and extremities. Pediatricians in the United Kingdom identified a small group of children presenting with shock and a multisystem inflammation, some of whom had coronary artery aneurysms, and a further group of less severely ill children with a Kawasaki-like disease. Based on the review of clinical and laboratory features, a case definition of the syndrome named “pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS)” was formulated by experts in the United Kingdom and published by the Royal College of Paediatrics and Child Health [100].