Analyzing the hematological profile of COVID-19 patients, a state of hypercoagulability emerged. In fact, high plasma levels of reactive protein C, fibrinogen, D-dimer and ferritin, associated with thrombocytopenia, were found in these patients [71,82]. Recently, clinical and autopsy reports from China and the U.S. confirm the development of disseminated intravascular coagulation following SARS-CoV-2 infection, with evidence of microangiopathy in several organs. In fact, the activation of macrophages associated with COVID-19, the storm of cytokines and the molecular proteins associated with the damage can cause both tissue factors’ release and the activation of coagulation factors predisposing to hypercoagulability.