The expression of ACE-2 has been shown not only in the lung but also in the liver, stomach, ileum, colon, esophagus and kidney [47]. These data associated with the evidence that AKI (7%), myocardial dysfunction with acute cardiovascular events (12%) and gastrointestinal disorders are among the most frequent clinical manifestations of COVID-19 [23], suggesting that SARS-CoV-2 can infect these organs. However, whether SARS-CoV-2 replication occurs in these organs causing functional damage and contributing to the systemic spread of the virus is not yet clear.