Proliferation and maturational fate of neural progenitors and oligodendroglia • HIVSF162 (R5) • HIVIIIB (X4) No Morphine • ↓ Proliferation of immature neural and OL progenitors with Tat + morphine • ↓ NPC DNA synthesis with R5-tropic HIV + morphine • ↑ NPC DNA synthesis with X4-tropic HIV + morphine Mouse, Tat tg; Mouse, Human, primary neural progenitors (Hahn et al. 2012)