MOR-coupling efficacy to G proteins Tat1–86 No • Morphine (acute, 10 mg/kg i.p.) • Morphine, DAMGO (ex vivo) ↓ [35S]GTPγS binding in NAc Shell, CPu, amygdala, PFC, but not hippocampus, with morphine in Tat mice Mouse, Tat tg, males (Hahn et al. 2016)