SIV gene mutation/evolutiontat Mixture of SIV17-EFr, SHIVKU _1B, SHIV89.6P No Morphine
(5 mg/kg, i.m., t.i.d., 20–56 weeks) • ↑ Viral load; ↓ CD4 counts
• tat evolution—inverse correlation with SIV progression
• ↓ tat diversity with morphine Rhesus macaques (Noel and Kumar 2006; Noel et al. 2006b)