HIV entry into the brain Mixture of SIV17-EFr, SHIVKU_1B, SHIV89.6P No Morphine (5 mg/kg i.m., b.i.d., ≤ 56 weeks) • ↑ CSF viral load • ↑ Viral migration through BBB for SHIVKU Rhesus macaques (Kumar et al. 2006)