findings (human) HIV progression and/or ARV adherence HIV cART • SUD • Prescription opioids for pain • ↑ Viral load with SUD • ↓ ARV adherence • ↑ Frequency of prescription drugs with pain + SUD Human (Denis et al. 2019) HIV cART OUD • ↓ Lasting viral suppression • ↓ Adherence to cART for 3 years Human (Lemons et al. 2019) HIV ARV naive Injection drug use ↓ CD4 counts Human (Meijerink et al. 2014) HIV encephalit