Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Acknowledgements Portions of this review were initially presented at the Satellite Symposium of the 25th SNIP Scientific Conference entitled, “Unraveling NeuroAIDS in the Presence of Substance Use Disorder” that was sponsored and organized by NIH/NIDA. Co-Chairs: Yu (Woody) Lin and Roger Sorensen (April 10, 2019) Funding This work was supported by the National Institute on Drug Abuse: R01 DA034231 (KFH), R01 DA044855 (KFH), R01 DA045588 (KFH), R01 DA018633 (KFH), R21 DA045630 (MM), and R01 DA045596 (SF). Compliance with Ethical Standards Conflict of Interest The authors declare that they have no conflict of interest.