Chlorpromazine (15) stopped the replication of SARS‐CoV‐1, MERS‐CoV, and HCoV‐229E. It is a neuroleptic drug used against schizophrenia; 253  here, it interferes with clathrin‐mediated endocytosis. Since, clathrin‐mediated endocytosis is a crucial port for viral entry into the host cell, used by MHV, 254 ,  255 ,  256  SARS‐CoV‐1, 99  and MERS‐CoV, 102  future clinical trials could help elucidate this drug's therapeutic potential against COVID‐19.