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PMC:7461420 / 94630-95717 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T343 157-162 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T445 225-229 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T446 533-539 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T447 544-561 Disease denotes allergic rhinitis http://purl.obolibrary.org/obo/MONDO_0011786
T448 544-552 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T449 553-561 Disease denotes rhinitis http://purl.obolibrary.org/obo/MONDO_0003014
T450 663-667 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T451 708-716 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T452 1069-1077 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1058 44-47 http://purl.obolibrary.org/obo/CLO_0054057 denotes 181
T1059 112-122 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T1060 131-136 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T1061 152-156 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T1062 152-156 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T1063 157-162 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T1064 208-216 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1065 497-498 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1066 568-569 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1067 629-630 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1068 680-681 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T1069 759-761 http://purl.obolibrary.org/obo/CLO_0037161 denotes en
T1070 881-889 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1071 916-917 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T703 24-29 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T704 164-175 Chemical denotes Niclosamide http://purl.obolibrary.org/obo/CHEBI_7553
T705 198-207 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T706 350-361 Chemical denotes Ciclesonide http://purl.obolibrary.org/obo/CHEBI_31397
T707 402-406 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T708 432-441 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T709 499-507 Chemical denotes cortisol http://purl.obolibrary.org/obo/CHEBI_17650
T710 640-654 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T711 640-649 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T712 650-654 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T713 759-761 Chemical denotes en http://purl.obolibrary.org/obo/CHEBI_30347
T714 827-831 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T715 871-880 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T126 302-311 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T127 302-311 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T21 533-539 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T22 544-561 Phenotype denotes allergic rhinitis http://purl.obolibrary.org/obo/HP_0003193

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2903 225-235 Species denotes SARS‐CoV‐2 Tax:2697049
2904 335-343 Species denotes MERS‐CoV Tax:1335626
2905 663-673 Species denotes SARS‐CoV‐2 Tax:2697049
2906 717-725 Species denotes patients Tax:9606
2907 31-42 Chemical denotes niclosamide MESH:D009534
2908 53-64 Chemical denotes ciclesonide MESH:C120481
2909 164-175 Chemical denotes Niclosamide MESH:D009534
2910 267-278 Chemical denotes niclosamide MESH:D009534
2911 350-361 Chemical denotes Ciclesonide MESH:C120481
2912 478-489 Chemical denotes niclosamide MESH:D009534
2913 499-507 Chemical denotes cortisol MESH:D006854
2914 614-625 Chemical denotes ciclesonide MESH:C120481
2915 1004-1015 Chemical denotes ciclesonide MESH:C120481
2916 533-539 Disease denotes asthma MESH:D001249
2917 544-561 Disease denotes allergic rhinitis MESH:D065631
2918 708-716 Disease denotes COVID‐19 MESH:C000657245
2919 1069-1077 Disease denotes COVID‐19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T840 0-163 Sentence denotes Among them two approved drugs, niclosamide (181) and ciclesonide (182; Figure 39), exhibited notable inhibitory activities against virus replication in Vero cells.
T841 164-252 Sentence denotes Niclosamide exhibited very potent antiviral activity against SARS‐CoV‐2 (IC50, 0.28 µM).
T842 253-344 Sentence denotes The action of niclosamide might be attributed to autophagy as it was reported for MERS‐CoV.
T843 345-490 Sentence denotes 239 Ciclesonide (182; Figure 39) is another interesting drug candidate with far lower antiviral potency (IC50, 4.33 µM) compared to niclosamide.
T844 491-562 Sentence denotes It is a cortisol derivative used to treat asthma and allergic rhinitis.
T845 563-674 Sentence denotes 241 A recent report by Matsuyama et al. confirmed ciclesonide as a possible antiviral drug against SARS‐CoV‐2.
T846 675-832 Sentence denotes 242 A treatment report of three COVID‐19 patients (https://www3.nhk.or.jp/nhkworld/en/news/20200303_20/) merits further clinical investigation of this drug.
T847 833-941 Sentence denotes The molecular target of ciclesonide's antiviral activity was revealed to be NSP15, a viral riboendonuclease.
T848 942-1087 Sentence denotes Together with its well‐established anti‐inflammatory effects, ciclesonide could offer an interesting option for the control of COVID‐19 symptoms.