Drugs  Class  MERS‐CoVEC50 (µM)  SARS‐CoV‐1EC50 (µM)
Emetine  Antibacterial agent  0.014  0.051
Chloroquine  Antiparasitic agent  6.27  6.53
Hydroxychloroquine  Antiparasitic agent  8.27  7.96
Mefloquine  Antiparasitic agent  7.41  15.55
Amodiaquine  Antiparasitic agent  6.21  1.27
Loperamide  Antidiarrheal agent  4.8  5.90
Lopinavir  HIV‐1 inhibitor  8.0  24.4
E‐64‐D  Cathepsin inhibitor  1.27  0.76
Gemcitabine  DNA metabolism inhibitor  1.21  4.95
Tamoxifen  Estrogen receptor inhibitor  10.11  92.88
Toremifene  Estrogen receptor inhibitor  12.91  11.96
Terconazole  Sterol metabolism inhibitor  12.20  15.32
Triparanol  Sterol metabolism inhibitor  5.28  ‐
Anisomycin  Protein‐processing inhibitor  0.003  0.19
Cycloheximide  Protein‐processing inhibitor  0.189  0.04
Homoharringtonine  Protein‐processing inhibitor  0.071  ‐
Benztropine  Neurotransmitter inhibitor  16.62  21.61
Fluspirilene  Neurotransmitter inhibitor  7.47  5.96
Thiothixene  Neurotransmitter inhibitor  9.29  5.31
Chlorpromazine  Neurotransmitter inhibitor  9.51  12.97
Fluphenazine  Neurotransmitter inhibitor  5.86  21.43
Promethazine  Neurotransmitter inhibitor  11.80  7.54
Astemizole  Neurotransmitter inhibitor  4.88  5.59
Chlorphenoxamine  Neurotransmitter inhibitor  12.64  20.03
Thiethylperazine  Neurotransmitter inhibitor  7.86  ‐
Triflupromazine  Neurotransmitter inhibitor  5.75  6.39
Clomipramine  Neurotransmitter inhibitor  9.33  13.23
Imatinib  Kinase signaling inhibitor  17.68  9.82
Dasatinib  Kinase signaling inhibitor  5.46  2.10