For viral entry, MERS‐CoV uses its spike protein (S) to interact with the host‐receptor DPP4, 37 ,  38 ,  39  also known as adenosine deaminase‐complexing protein‐2 or CD26. 37  MERS‐CoV was also the first virus reported to use this particular path. 35 ,  37  DPP4 is a type II transmembrane glycoprotein, that forms homodimers on the cell surface, and it is involved in the cleavage of dipeptides. 37 ,  40  In humans, DPP4 is predominantly found on the bronchial epithelial and alveolar cells in the lower lungs. 40 ,  41