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PMC:7461420 / 10679-35550 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T71 43-50 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 208-214 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T73 365-372 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T74 379-389 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T75 502-509 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T76 543-550 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T77 1467-1473 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T78 1699-1705 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T79 2050-2057 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T80 2130-2137 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T81 2346-2350 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T82 3554-3558 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T83 3812-3823 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T84 4095-4102 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T85 4454-4461 Body_part denotes glycine http://purl.org/sig/ont/fma/fma82753
T86 4924-4931 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T87 5038-5045 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T88 5175-5187 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T89 5218-5230 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T90 5218-5222 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T91 5363-5377 Body_part denotes alveolar cells http://purl.org/sig/ont/fma/fma62499
T92 5372-5377 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T93 5391-5396 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T94 5637-5642 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T95 5773-5778 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T96 5865-5876 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T97 5935-5940 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T98 6000-6007 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 6073-6076 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T100 6286-6294 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T101 6533-6540 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T102 6711-6715 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T103 6771-6779 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T104 7528-7535 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T105 7571-7576 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T106 8407-8412 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 8491-8498 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T108 8582-8587 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T109 8928-8933 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T110 8977-8988 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T111 9001-9005 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T112 9030-9055 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T113 9050-9055 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T114 9100-9107 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T115 9139-9149 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T116 9202-9209 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T117 9228-9235 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T118 9354-9358 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T119 9412-9419 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T120 9501-9506 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T121 9891-9895 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T122 10426-10430 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T123 10497-10507 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T124 10552-10562 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T125 11491-11505 Body_part denotes late endosomal http://purl.org/sig/ont/fma/fma67467
T126 11510-11519 Body_part denotes lysosomal http://purl.org/sig/ont/fma/fma63836
T127 11573-11582 Body_part denotes endosomes http://purl.org/sig/ont/fma/fma67180
T128 11586-11595 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T129 11668-11672 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 11791-11800 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T131 12131-12136 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T132 12205-12221 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T133 12216-12221 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T134 12717-12722 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T135 14009-14012 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T136 16400-16404 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T137 16446-16453 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T138 16483-16488 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T139 16666-16670 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T140 17210-17215 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T141 17412-17417 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T142 17489-17494 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T143 17634-17639 Body_part denotes joint http://purl.org/sig/ont/fma/fma7490
T144 18116-18120 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T145 18194-18199 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T146 18209-18217 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T147 18219-18228 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T148 18344-18352 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T149 18400-18407 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T150 18490-18504 Body_part denotes late endosomes http://purl.org/sig/ont/fma/fma67467
T151 18527-18535 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180
T152 18611-18625 Body_part denotes late endosomes http://purl.org/sig/ont/fma/fma67467
T153 18630-18639 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T154 18675-18682 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T155 18794-18798 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 18839-18844 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T157 18933-18942 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T158 19059-19066 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T159 19112-19119 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T160 19371-19376 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T161 19390-19396 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T162 19498-19523 Body_part denotes neurotransmitter receptor http://purl.org/sig/ont/fma/fma67184
T163 19683-19690 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T164 19730-19738 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T165 19953-19969 Body_part denotes Neurotransmitter http://purl.org/sig/ont/fma/fma302832
T166 19991-19999 Body_part denotes clathrin http://purl.org/sig/ont/fma/fma62262
T167 20076-20082 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T168 20280-20287 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T169 20297-20301 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T170 20408-20417 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T171 20666-20672 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T172 20946-20951 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T173 21078-21086 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T174 21120-21126 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T175 21229-21235 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T176 21383-21395 Body_part denotes glycopeptide http://purl.org/sig/ont/fma/fma82784
T177 21959-21967 Body_part denotes cysteine http://purl.org/sig/ont/fma/fma82751
T178 22051-22058 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T179 22096-22110 Body_part denotes late endosomes http://purl.org/sig/ont/fma/fma67467
T180 22184-22188 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T181 23003-23009 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T182 23015-23020 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T183 23086-23103 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T184 23098-23103 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 23251-23255 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T186 23433-23438 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T187 23738-23742 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T188 23769-23773 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T189 24007-24014 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T190 24090-24097 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T191 24141-24146 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T192 24331-24344 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T193 24331-24335 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T194 24625-24630 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T4 5935-5940 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T5 6711-6715 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T6 8977-8988 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T7 9001-9005 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T8 9354-9358 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 9501-9506 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 9891-9895 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T11 10159-10183 Body_part denotes renin‐angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T12 10291-10315 Body_part denotes renin‐angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T13 10426-10430 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T14 12717-12722 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T15 14009-14012 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T16 17210-17215 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T17 17489-17494 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T18 18116-18120 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T19 21120-21126 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T20 21229-21235 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T21 23003-23009 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T22 23769-23773 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T50 218-222 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T51 293-297 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T52 352-356 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T53 489-493 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T54 562-566 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T55 820-829 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T56 879-883 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T57 899-903 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T58 986-990 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 1003-1007 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T60 1055-1059 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T61 1076-1080 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T62 1150-1154 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T63 1171-1175 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T64 1204-1208 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T65 1225-1229 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T66 1283-1287 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T67 1295-1342 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T68 1295-1328 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T69 1486-1490 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T70 1587-1591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T71 1648-1652 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T72 1757-1761 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T73 1769-1773 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T74 1916-1920 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T75 2066-2070 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T76 2091-2095 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T77 2187-2191 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T78 2294-2298 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T79 2595-2599 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T80 2774-2778 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T81 2934-2938 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T82 2949-2953 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T83 3009-3013 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T84 3041-3045 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 3183-3187 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T86 3195-3199 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T87 4227-4231 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T88 4373-4377 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T89 4567-4571 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T90 4730-4734 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T91 4783-4787 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T92 5602-5611 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T93 5917-5921 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T94 6330-6335 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T95 6377-6393 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T96 6408-6424 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T97 6505-6509 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T98 6520-6524 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 6647-6651 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T100 7043-7047 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 7514-7518 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T102 8085-8089 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 8216-8220 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T104 8352-8356 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 8694-8698 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 8741-8745 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T107 8770-8774 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T108 8863-8872 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T109 8874-8878 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 9061-9065 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T111 9113-9117 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 9189-9193 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T113 9215-9219 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T114 9801-9813 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T115 9844-9879 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T116 9850-9879 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T117 9881-9885 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T118 9930-9934 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 9944-9948 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T120 10750-10773 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T121 11155-11159 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T122 11224-11228 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T123 11234-11267 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T124 11381-11388 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T125 11393-11402 Disease denotes amebiasis http://purl.obolibrary.org/obo/MONDO_0005644
T126 11873-11877 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T127 11932-11936 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T128 11958-11962 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T129 11994-11998 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T130 12076-12080 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T131 12284-12288 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 12295-12304 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T133 12375-12379 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 12480-12484 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T135 12508-12512 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 12653-12661 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T137 12717-12730 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T138 12734-12742 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T139 13044-13052 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T140 13164-13168 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T141 13338-13342 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T142 13347-13352 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T143 13490-13506 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T144 14351-14359 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T145 14469-14477 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T146 14548-14556 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T147 14921-14931 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T148 15073-15081 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T149 15202-15221 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T150 15226-15233 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T151 16194-16198 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 16609-16618 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T153 16759-16763 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 16805-16809 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T155 16867-16875 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T156 16910-16914 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T157 17013-17016 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T158 17028-17036 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T159 17210-17223 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T160 17484-17503 Disease denotes high blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T161 17568-17576 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T162 17686-17689 Disease denotes AHA http://purl.obolibrary.org/obo/MONDO_0020108
T163 17848-17851 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T164 17971-17975 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T165 18116-18129 Disease denotes lung diseases http://purl.obolibrary.org/obo/MONDO_0005275
T166 18761-18765 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T167 19260-19270 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T168 19344-19348 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T169 19644-19648 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T170 19820-19831 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T171 19820-19829 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T172 19839-19849 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T173 19850-19860 Disease denotes bronchitis http://purl.obolibrary.org/obo/MONDO_0003781
T174 19885-19894 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T175 20134-20138 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 20267-20271 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T177 20484-20487 Disease denotes EST http://purl.obolibrary.org/obo/MONDO_0023726
T178 20550-20559 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T179 20749-20753 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T180 20923-20927 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 21147-21151 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T182 21423-21433 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T183 21590-21594 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T184 21616-21621 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T185 21732-21736 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T186 21874-21882 Disease denotes COVID‐19 http://purl.obolibrary.org/obo/MONDO_0100096
T187 22007-22016 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T188 22253-22262 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T189 22744-22748 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T190 22947-22952 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T191 22953-22968 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T192 22959-22968 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T193 23178-23182 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T194 23187-23192 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T195 23193-23209 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T196 24603-24607 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T197 24721-24725 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T198 24831-24835 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 24842-24851 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T111 3-8 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes VIRUS
T112 122-127 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T113 229-232 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T114 328-331 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T115 517-518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T116 696-698 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T117 1052-1053 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T118 1131-1133 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T119 1147-1148 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T120 1185-1187 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T121 1185-1187 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T122 1519-1524 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T123 1576-1577 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T124 1691-1692 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T125 1717-1718 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T126 1719-1722 http://purl.obolibrary.org/obo/NCBITaxon_9397 denotes bat
T127 1885-1890 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T128 2083-2085 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T129 2108-2110 http://purl.obolibrary.org/obo/CLO_0001627 denotes aa
T130 2138-2141 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T131 2155-2157 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T132 2162-2164 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T133 2162-2164 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T134 2170-2172 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T135 2198-2201 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T136 2202-2203 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 2335-2340 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T138 2346-2350 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T139 2401-2402 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T140 2967-2969 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T141 3257-3258 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T142 3422-3430 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T143 3438-3444 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T144 3541-3558 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity for cell
T145 3606-3607 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T146 3713-3714 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T147 3831-3837 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T148 4009-4011 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T149 4022-4023 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T150 4034-4042 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T151 4205-4207 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T152 4280-4288 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T153 4289-4291 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T154 4356-4364 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T155 4399-4407 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T156 4481-4488 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T157 4489-4491 http://purl.obolibrary.org/obo/CLO_0008337 denotes P4
T158 4502-4504 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T159 4530-4537 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T160 4548-4551 http://purl.obolibrary.org/obo/CLO_0001310 denotes 351
T161 4565-4566 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T162 4654-4656 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T163 4688-4689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T164 4810-4815 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T165 4833-4834 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T166 4864-4871 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T167 5089-5094 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T168 5133-5135 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T169 5151-5152 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T170 5218-5222 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T171 5295-5301 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T172 5348-5358 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T173 5372-5377 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T174 5391-5396 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T175 5404-5406 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T176 5423-5425 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T177 5508-5509 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T178 5567-5573 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T179 5631-5636 http://purl.obolibrary.org/obo/CLO_0009989 denotes Huh‐7
T180 5637-5642 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T181 5765-5778 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T182 5801-5802 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T183 5825-5826 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T184 5878-5879 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T185 5888-5896 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T186 5951-5953 http://purl.obolibrary.org/obo/CLO_0003622 denotes HB
T187 6051-6058 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T188 6098-6101 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T189 6158-6166 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T190 6219-6220 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T191 6258-6265 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T192 6309-6314 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T193 6323-6328 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T194 6336-6341 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T195 6394-6399 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T196 6425-6430 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T197 6458-6463 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T198 6477-6479 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T199 6547-6548 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T200 6761-6769 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T201 7067-7068 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T202 7227-7228 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T203 7332-7334 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T204 7525-7527 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T205 7525-7527 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T206 7563-7576 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T207 7869-7872 http://purl.obolibrary.org/obo/CLO_0001203 denotes 232
T208 8068-8076 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T209 8131-8132 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T210 8184-8186 http://purl.obolibrary.org/obo/CLO_0006987 denotes J1
T211 8204-8205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T212 8331-8332 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T213 8407-8412 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T214 8577-8581 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T215 8577-8581 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T216 8582-8587 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T217 8616-8618 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T218 8826-8833 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T219 8909-8910 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 8928-8933 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T221 8941-8944 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T222 8977-8988 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T223 9001-9005 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T224 9001-9005 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T225 9039-9049 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T226 9050-9055 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T227 9079-9089 http://purl.obolibrary.org/obo/CLO_0009900 denotes 76% of its
T228 9133-9134 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T229 9277-9279 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T230 9354-9358 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T231 9354-9358 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T232 9365-9366 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T233 9403-9411 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T234 9501-9506 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T235 9501-9506 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T236 9559-9567 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T237 9891-9895 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T238 9891-9895 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T239 10185-10186 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T240 10231-10239 http://purl.obolibrary.org/obo/PR_000018263 denotes peptides
T241 10244-10245 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T242 10435-10436 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T243 10552-10570 http://purl.obolibrary.org/obo/CHEBI_33708 denotes amino acid residue
T244 10552-10570 http://purl.obolibrary.org/obo/PR_000036907 denotes amino acid residue
T245 10657-10658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 10695-10698 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T247 10715-10716 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 10807-10808 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 11025-11026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 11309-11310 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 11459-11460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 11510-11519 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomal
T253 11586-11595 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T254 11601-11606 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T255 11668-11672 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T256 11908-11914 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T257 12059-12067 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T258 12126-12130 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T259 12126-12130 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T260 12131-12136 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T261 12181-12189 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T262 12205-12215 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T263 12216-12233 http://purl.obolibrary.org/obo/CL_0000003 denotes cells and in vivo
T264 12541-12544 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T265 12669-12671 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T266 12717-12722 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T267 12717-12722 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T268 12717-12722 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T269 12717-12722 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T270 12955-12959 http://purl.obolibrary.org/obo/NCBITaxon_117565 denotes fish
T271 13314-13320 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T272 13353-13358 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T273 13512-13513 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T274 13621-13622 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T275 13834-13841 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T276 13886-13891 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T277 14009-14012 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arm
T278 14188-14190 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T279 14434-14435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T280 14597-14598 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T281 14684-14685 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T282 15334-15335 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T283 15373-15374 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T284 15504-15505 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T285 15736-15737 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T286 15790-15794 http://purl.obolibrary.org/obo/CLO_0001757 denotes at 1
T287 15832-15834 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T288 15987-15995 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T289 16031-16037 http://purl.obolibrary.org/obo/CLO_0008462 denotes pM. 85
T290 16118-16123 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T291 16163-16164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T292 16235-16241 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T293 16286-16293 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T294 16387-16388 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T295 16389-16394 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T296 16400-16404 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T297 16483-16488 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T298 16497-16498 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T299 16564-16565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T300 16655-16660 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T301 16666-16670 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T302 16721-16722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T303 17210-17215 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T304 17210-17215 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T305 17210-17215 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T306 17210-17215 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T307 17412-17417 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T308 17489-17494 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T309 17489-17494 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T310 17543-17544 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T311 17632-17633 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T312 17634-17639 http://purl.obolibrary.org/obo/UBERON_0000982 denotes joint
T313 17634-17639 http://purl.obolibrary.org/obo/UBERON_0004905 denotes joint
T314 17724-17725 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T315 17867-17869 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T316 18085-18086 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T317 18116-18120 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T318 18116-18120 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T319 18194-18199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T320 18562-18572 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T321 18630-18639 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T322 18659-18668 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T323 18794-18798 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T324 18839-18844 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T325 18850-18858 http://purl.obolibrary.org/obo/UBERON_0000158 denotes Membrane
T326 19019-19025 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T327 19074-19076 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T328 19077-19079 http://purl.obolibrary.org/obo/CLO_0008922 denotes S2
T329 19077-19079 http://purl.obolibrary.org/obo/CLO_0050052 denotes S2
T330 19097-19105 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T331 19124-19132 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T332 19272-19273 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T333 19364-19376 http://purl.obolibrary.org/obo/CLO_0051719 denotes VeroE6 cells
T334 19388-19389 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T335 19411-19420 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T336 19467-19475 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T337 19490-19493 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T338 19728-19729 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T339 19804-19809 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T340 19832-19837 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T341 19861-19866 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T342 19879-19884 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T343 19895-19900 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T344 20112-20114 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T345 20132-20133 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T346 20173-20181 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T347 20204-20205 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T348 20297-20301 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T349 20369-20371 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T350 20467-20468 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T351 20489-20490 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T352 20516-20518 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T353 20567-20575 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T354 20591-20598 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T355 20682-20683 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T356 20701-20704 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T357 20836-20837 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T358 20858-20860 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T359 20872-20873 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T360 20946-20951 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T361 20955-20956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T362 20997-20999 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T363 21003-21004 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T364 21076-21077 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T365 21248-21254 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T366 21323-21331 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T367 21381-21382 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T368 21453-21461 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T369 21622-21627 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T370 21687-21690 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T371 21831-21832 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T372 21936-21941 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T373 21957-21958 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T374 21992-21993 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T375 22031-22041 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T376 22064-22065 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T377 22178-22183 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T378 22184-22188 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T379 22212-22213 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T380 22264-22267 http://purl.obolibrary.org/obo/CLO_0053001 denotes 114
T381 22518-22526 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T382 22632-22640 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T383 22701-22703 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T384 22756-22757 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T385 22860-22862 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T386 22918-22920 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T387 22953-22958 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T388 22987-22992 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T389 22993-23009 http://www.ebi.ac.uk/efo/EFO_0000927 denotes embryonic kidney
T390 23010-23014 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T391 23010-23014 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T392 23010-23014 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T393 23015-23020 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T394 23073-23078 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T395 23079-23085 http://www.ebi.ac.uk/efo/EFO_0000265 denotes aortic
T396 23086-23103 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T397 23135-23136 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T398 23193-23198 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T399 23211-23214 http://purl.obolibrary.org/obo/CLO_0001046 denotes 116
T400 23249-23255 http://purl.obolibrary.org/obo/CLO_0001020 denotes a cell
T401 23400-23401 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T402 23428-23432 http://purl.obolibrary.org/obo/CLO_0050894 denotes 293T
T403 23428-23432 http://purl.obolibrary.org/obo/CLO_0051650 denotes 293T
T404 23428-23432 http://purl.obolibrary.org/obo/CLO_0052052 denotes 293T
T405 23433-23438 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T406 23527-23529 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T407 23637-23640 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T408 23675-23681 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T409 23738-23742 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T410 23908-23914 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T411 24133-24146 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T412 24251-24253 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T413 24281-24282 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T414 24325-24330 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T415 24331-24335 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T416 24336-24344 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T417 24434-24435 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T418 24625-24630 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T419 24637-24638 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T420 24806-24808 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T421 24868-24871 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T67 43-50 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T68 365-372 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 379-389 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T70 502-509 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T71 543-550 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T72 1116-1118 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T73 1185-1187 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T74 1248-1250 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T75 1262-1270 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T76 1578-1583 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T77 1857-1859 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T78 2050-2057 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T79 2130-2137 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T80 2162-2164 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T81 2574-2576 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T82 2681-2689 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T83 3222-3232 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T84 3375-3384 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T85 3487-3493 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T86 3701-3706 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T87 3725-3730 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T88 3739-3749 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T89 3812-3823 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T90 3812-3817 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T91 3818-3823 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T92 4034-4042 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T93 4095-4102 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T94 4280-4288 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T95 4289-4291 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T96 4389-4398 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T97 4454-4461 Chemical denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T100 4481-4488 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T101 4489-4491 Chemical denotes P4 http://purl.obolibrary.org/obo/CHEBI_35895
T102 4530-4537 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T103 4767-4769 Chemical denotes EM http://purl.obolibrary.org/obo/CHEBI_73507
T104 4864-4871 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T105 4924-4931 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T106 5007-5016 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T107 5038-5045 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T108 5158-5160 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T109 5175-5187 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T110 5270-5280 Chemical denotes dipeptides http://purl.obolibrary.org/obo/CHEBI_46761
T111 5865-5876 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T112 5865-5870 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T113 5871-5876 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T114 6000-6007 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T115 6051-6058 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T116 6073-6093 Chemical denotes HIV fusion inhibitor http://purl.obolibrary.org/obo/CHEBI_59886
T117 6084-6093 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T118 6158-6166 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T119 6182-6192 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T120 6199-6208 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T121 6286-6294 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T122 6533-6540 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T123 6594-6604 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T124 6671-6679 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T125 6686-6696 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T126 6761-6769 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T127 6771-6779 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T128 6802-6811 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T129 6959-6966 Chemical denotes oxazole http://purl.obolibrary.org/obo/CHEBI_35597|http://purl.obolibrary.org/obo/CHEBI_35790
T131 6967-6978 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T133 7025-7034 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T134 7123-7132 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T135 7429-7438 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T136 7462-7470 Chemical denotes luteolin http://purl.obolibrary.org/obo/CHEBI_15864|http://purl.obolibrary.org/obo/CHEBI_57545
T138 7525-7527 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T139 7528-7535 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T140 7710-7712 Chemical denotes SI http://purl.obolibrary.org/obo/CHEBI_90326
T141 7934-7943 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T142 8005-8014 Chemical denotes Quercetin http://purl.obolibrary.org/obo/CHEBI_16243
T143 8058-8067 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T144 8180-8183 Chemical denotes ADS http://purl.obolibrary.org/obo/CHEBI_73344
T145 8239-8248 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T146 8460-8469 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T147 8491-8498 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T148 9100-9107 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 9139-9149 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T150 9139-9144 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T151 9145-9149 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T152 9202-9209 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T153 9228-9235 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T154 9412-9419 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 9460-9471 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T156 9473-9476 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T157 9555-9558 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T158 9559-9567 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T159 9648-9651 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T160 9675-9678 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T161 9679-9681 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T162 9698-9707 Chemical denotes dipeptide http://purl.obolibrary.org/obo/CHEBI_46761
T163 9712-9715 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T166 9722-9725 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T167 9726-9728 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T168 9986-9996 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T169 10009-10023 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T172 10009-10020 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T173 10021-10023 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T174 10095-10098 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T175 10099-10101 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T176 10165-10176 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T177 10211-10222 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T178 10231-10239 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T179 10297-10308 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T180 10322-10333 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T181 10437-10441 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T183 10497-10507 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T184 10497-10502 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T185 10503-10507 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T186 10552-10570 Chemical denotes amino acid residue http://purl.obolibrary.org/obo/CHEBI_33708
T187 10552-10562 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T188 10552-10557 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T189 10558-10562 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T190 10572-10575 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T193 10579-10582 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T195 10589-10592 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T196 10599-10602 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T197 10603-10605 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T198 10632-10635 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T199 10646-10649 Chemical denotes Ang http://purl.obolibrary.org/obo/CHEBI_48433
T200 10659-10670 Chemical denotes vasodilator http://purl.obolibrary.org/obo/CHEBI_35620
T201 10929-10938 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T202 10958-10967 Chemical denotes aziridine http://purl.obolibrary.org/obo/CHEBI_30969
T203 10968-10978 Chemical denotes ethanamine http://purl.obolibrary.org/obo/CHEBI_15862
T204 11193-11204 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T205 11280-11291 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T206 11437-11446 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T207 11733-11744 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T208 11810-11812 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T210 11882-11893 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T211 12268-12279 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T212 12529-12540 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T213 12920-12931 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T214 12932-12941 Chemical denotes phosphate http://purl.obolibrary.org/obo/CHEBI_18367|http://purl.obolibrary.org/obo/CHEBI_26020|http://purl.obolibrary.org/obo/CHEBI_35780|http://purl.obolibrary.org/obo/CHEBI_43474
T218 13103-13107 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T219 13261-13279 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T220 13284-13296 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T221 13540-13558 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T222 13602-13614 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T223 13728-13746 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T224 13797-13809 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T225 14056-14061 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T226 14112-14117 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T227 14202-14213 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T228 14233-14251 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T229 14451-14455 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T230 14610-14628 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T231 14632-14643 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T232 14686-14695 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T233 14704-14716 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T234 14721-14735 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T235 14835-14839 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T236 15013-15018 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T237 15112-15123 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T238 15128-15146 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T239 15312-15330 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T240 15747-15756 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T241 15812-15822 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T242 16083-16091 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T243 16092-16101 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T244 16247-16251 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T246 16286-16293 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T247 16307-16316 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T248 16446-16453 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T249 16581-16595 Chemical denotes antiviral drug http://purl.obolibrary.org/obo/CHEBI_36044
T250 16581-16590 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T251 16591-16595 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T252 17531-17536 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T253 17682-17685 Chemical denotes ACC http://purl.obolibrary.org/obo/CHEBI_18053|http://purl.obolibrary.org/obo/CHEBI_30526
T255 17686-17689 Chemical denotes AHA http://purl.obolibrary.org/obo/CHEBI_27777
T256 18163-18173 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T257 18400-18407 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T258 18675-18682 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T259 19059-19066 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T260 19077-19079 Chemical denotes S2 http://purl.obolibrary.org/obo/CHEBI_29387
T261 19112-19119 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T262 19390-19396 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T263 19498-19514 Chemical denotes neurotransmitter http://purl.obolibrary.org/obo/CHEBI_25512
T264 19533-19547 Chemical denotes chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647
T265 19554-19566 Chemical denotes promethazine http://purl.obolibrary.org/obo/CHEBI_8461
T266 19577-19589 Chemical denotes fluphenazine http://purl.obolibrary.org/obo/CHEBI_5123
T267 19683-19690 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T268 19712-19726 Chemical denotes Chlorpromazine http://purl.obolibrary.org/obo/CHEBI_3647
T269 19760-19769 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T270 19970-19980 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T271 20076-20101 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T272 20076-20082 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T273 20083-20101 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T275 20092-20101 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T276 20102-20110 Chemical denotes camostat http://purl.obolibrary.org/obo/CHEBI_135632
T277 20145-20154 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T278 20280-20287 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T279 20501-20510 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T280 20666-20672 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T281 20884-20893 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T282 21078-21105 Chemical denotes cysteine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64152
T283 21078-21086 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T284 21087-21105 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T286 21096-21105 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T287 21313-21322 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T288 21383-21395 Chemical denotes glycopeptide http://purl.obolibrary.org/obo/CHEBI_24396
T289 21396-21406 Chemical denotes antibiotic http://purl.obolibrary.org/obo/CHEBI_33281
T290 21467-21478 Chemical denotes methicillin http://purl.obolibrary.org/obo/CHEBI_6827
T291 21556-21567 Chemical denotes teicoplanin http://purl.obolibrary.org/obo/CHEBI_29687
T292 21799-21810 Chemical denotes teicoplanin http://purl.obolibrary.org/obo/CHEBI_29687
T293 21900-21909 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T294 21913-21935 Chemical denotes cathepsin L inhibitors http://purl.obolibrary.org/obo/CHEBI_70821
T295 21925-21935 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T296 21959-21967 Chemical denotes cysteine http://purl.obolibrary.org/obo/CHEBI_15356
T297 22051-22058 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T298 22147-22156 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T299 22323-22332 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T300 22594-22616 Chemical denotes Cathepsin L inhibitors http://purl.obolibrary.org/obo/CHEBI_70821
T301 22606-22616 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T302 22622-22631 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T303 22730-22740 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T304 23329-23338 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T305 23611-23621 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T306 23718-23722 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T307 23881-23887 Chemical denotes emodin http://purl.obolibrary.org/obo/CHEBI_42223|http://purl.obolibrary.org/obo/CHEBI_77659
T309 24007-24014 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T310 24090-24097 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T311 24283-24292 Chemical denotes benzamide http://purl.obolibrary.org/obo/CHEBI_28179
T312 24376-24385 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T313 24569-24578 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T314 24788-24797 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T13 2886-2890 http://purl.obolibrary.org/obo/GO_0003968 denotes RdRP
T14 5888-5903 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T15 8385-8412 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry into host cells
T16 8391-8406 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into host
T17 8453-8469 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitor
T18 9321-9330 http://purl.obolibrary.org/obo/GO_0016032 denotes virulence
T19 9321-9330 http://purl.obolibrary.org/obo/GO_0009405 denotes virulence
T20 9501-9527 http://purl.obolibrary.org/obo/GO_0008217 denotes blood pressure homeostasis
T21 9516-9527 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T22 9801-9813 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T23 12415-12437 http://purl.obolibrary.org/obo/GO_0033578 denotes terminal glycosylation
T24 12424-12437 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T25 13490-13506 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T26 15616-15626 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T27 16400-16411 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T28 16400-16411 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T29 16400-16411 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T30 16400-16411 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T31 16666-16677 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T32 16666-16677 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T33 16666-16677 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T34 16666-16677 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T35 18506-18519 http://purl.obolibrary.org/obo/GO_0045851 denotes Acidification
T36 18597-18607 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T37 18850-18865 http://purl.obolibrary.org/obo/GO_0061025 denotes Membrane fusion
T38 19124-19139 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T39 19324-19340 http://purl.obolibrary.org/obo/GO_0019058 denotes viral life cycle
T40 19467-19482 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T41 20297-20308 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T42 20297-20308 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T43 20297-20308 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T44 20297-20308 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T45 23354-23364 http://purl.obolibrary.org/obo/GO_0004175 denotes proteinase
T46 23743-23749 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T47 23743-23749 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T48 24336-24351 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T49 24739-24748 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 6377-6393 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T7 6408-6424 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T8 9850-9870 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T9 10750-10773 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T10 14909-14931 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T11 15202-15221 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T12 17484-17503 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T13 18116-18129 Phenotype denotes lung diseases http://purl.obolibrary.org/obo/HP_0002088
T14 19820-19829 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T15 19850-19860 Phenotype denotes bronchitis http://purl.obolibrary.org/obo/HP_0012387
T16 19885-19894 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
372 37-42 Gene denotes spike Gene:43740568
373 648-652 Gene denotes ACE2 Gene:59272
374 781-785 Gene denotes ACE2 Gene:59272
375 890-894 Gene denotes ACE2 Gene:59272
376 910-914 Gene denotes ACE2 Gene:59272
377 580-581 Gene denotes S Gene:43740568
378 541-542 Gene denotes S Gene:43740568
379 500-501 Gene denotes S Gene:43740568
380 363-364 Gene denotes S Gene:43740568
381 573-578 Gene denotes spike Gene:43740568
382 218-228 Species denotes SARS‐CoV‐2 Tax:2697049
383 293-301 Species denotes SARS‐CoV Tax:694009
384 332-335 Species denotes CoV Tax:11118
385 352-362 Species denotes SARS‐CoV‐2 Tax:2697049
386 459-463 Species denotes CoVs Tax:11118
387 489-499 Species denotes SARS‐CoV‐2 Tax:2697049
388 562-572 Species denotes SARS‐CoV‐2 Tax:2697049
389 879-889 Species denotes SARS‐CoV‐2 Tax:2697049
390 899-907 Species denotes SARS‐CoV Tax:694009
391 820-829 Disease denotes infection MESH:D007239
406 1215-1216 Gene denotes S Gene:43740568
407 1161-1162 Gene denotes S Gene:43740568
408 1066-1067 Gene denotes S Gene:43740568
409 997-998 Gene denotes S Gene:43740568
410 986-996 Species denotes SARS‐CoV‐2 Tax:2697049
411 1003-1011 Species denotes SARS‐CoV Tax:694009
412 1055-1065 Species denotes SARS‐CoV‐2 Tax:2697049
413 1076-1084 Species denotes SARS‐CoV Tax:694009
414 1150-1160 Species denotes SARS‐CoV‐2 Tax:2697049
415 1171-1179 Species denotes SARS‐CoV Tax:694009
416 1204-1214 Species denotes SARS‐CoV‐2 Tax:2697049
417 1225-1233 Species denotes SARS‐CoV Tax:694009
418 1283-1293 Species denotes SARS‐CoV‐2 Tax:2697049
419 1295-1342 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
430 1789-1793 Gene denotes ACE2 Gene:59272
431 1891-1895 Gene denotes ACE2 Gene:59272
432 1486-1496 Species denotes SARS‐CoV‐2 Tax:2697049
433 1597-1601 Species denotes CoVs Tax:11118
434 1648-1658 Species denotes SARS‐CoV‐2 Tax:2697049
435 1719-1734 Species denotes bat coronavirus Tax:1508220
436 1757-1765 Species denotes SARS‐CoV Tax:694009
437 1769-1779 Species denotes SARS‐CoV‐2 Tax:2697049
438 1885-1890 Species denotes human Tax:9606
439 1916-1926 Species denotes SARS‐CoV‐2 Tax:2697049
455 2044-2049 Gene denotes spike Gene:43740568
456 2124-2129 Gene denotes spike Gene:43740568
457 2251-2255 Gene denotes ACE2 Gene:59272
458 2496-2500 Gene denotes ACE2 Gene:59272
459 2612-2616 Gene denotes ACE2 Gene:59272
460 2730-2734 Gene denotes ACE2 Gene:59272
461 2606-2611 Gene denotes spike Gene:43740568
462 2066-2074 Species denotes SARS‐CoV Tax:694009
463 2091-2101 Species denotes SARS‐CoV‐2 Tax:2697049
464 2187-2195 Species denotes SARS‐CoV Tax:694009
465 2294-2304 Species denotes SARS‐CoV‐2 Tax:2697049
466 2335-2340 Species denotes human Tax:9606
467 2595-2603 Species denotes SARS‐CoV Tax:694009
468 2774-2784 Species denotes SARS‐CoV‐2 Tax:2697049
469 2681-2689 Chemical denotes hydrogen MESH:D006859
478 2886-2890 Gene denotes RdRP Gene:43740578
479 3195-3201 Gene denotes SARS‐2 Gene:54938
480 2900-2904 Gene denotes Mpro Gene:8673700
481 2934-2944 Species denotes SARS‐CoV‐2 Tax:2697049
482 2949-2957 Species denotes SARS‐CoV Tax:694009
483 3009-3019 Species denotes SARS‐CoV‐2 Tax:2697049
484 3041-3049 Species denotes SARS‐CoV Tax:694009
485 3202-3206 Species denotes CoVs Tax:11118
499 3919-3923 Gene denotes ACE2 Gene:59272
500 4108-4112 Gene denotes ACE2 Gene:59272
501 4517-4521 Gene denotes ACE2 Gene:59272
502 4816-4820 Gene denotes ACE2 Gene:59272
503 4227-4235 Species denotes SARS‐CoV Tax:694009
504 4373-4381 Species denotes SARS‐CoV Tax:694009
505 4567-4575 Species denotes SARS‐CoV Tax:694009
506 4730-4740 Species denotes SARS‐CoV‐2 Tax:2697049
507 4783-4793 Species denotes SARS‐CoV‐2 Tax:2697049
508 4810-4815 Species denotes human Tax:9606
509 4454-4461 Chemical denotes glycine MESH:D005998
510 3995-4001 Disease denotes Hsiang
511 4627-4639 Disease denotes cytotoxicity MESH:D064420
522 4971-4975 Gene denotes DPP4 Gene:1803
523 5007-5047 Gene denotes adenosine deaminase‐complexing protein‐2 Gene:1803
524 5051-5055 Gene denotes CD26 Gene:1803
525 5143-5147 Gene denotes DPP4 Gene:1803
526 5303-5307 Gene denotes DPP4 Gene:1803
527 4918-4923 Gene denotes spike Gene:43740568
528 4900-4908 Species denotes MERS‐CoV Tax:1335626
529 5061-5069 Species denotes MERS‐CoV Tax:1335626
530 5295-5301 Species denotes humans Tax:9606
531 5270-5280 Chemical denotes dipeptides MESH:D004151
541 5615-5619 Gene denotes DPP4 Gene:1803
542 5473-5481 Species denotes MERS‐CoV Tax:1335626
543 5520-5525 Species denotes yeast Tax:4932
544 5660-5668 Species denotes MERS‐CoV Tax:1335626
545 5708-5716 Species denotes MERS‐CoV Tax:1335626
546 5602-5611 Disease denotes infection MESH:D007239
547 5751-5764 Disease denotes MERS‐infected MESH:D018352
548 5631-5636 CellLine denotes Huh‐7 CVCL:0336
549 5770-5772 CellLine denotes E6 CVCL:4582
561 6531-6532 Gene denotes S Gene:43740568
562 5917-5925 Species denotes SARS‐CoV Tax:694009
563 6303-6314 Species denotes Nipah virus Tax:121791
564 6316-6328 Species denotes Hendra virus Tax:63330
565 6330-6341 Species denotes Ebola virus Tax:1570291
566 6370-6399 Species denotes simian immunodeficiency virus Tax:11723
567 6401-6430 Species denotes feline immunodeficiency virus Tax:11673
568 6436-6463 Species denotes respiratory syncytial virus Tax:12814
569 6505-6513 Species denotes SARS‐CoV Tax:694009
570 6520-6530 Species denotes SARS‐CoV‐2 Tax:2697049
571 6647-6657 Species denotes SARS‐CoV‐2 Tax:2697049
576 7149-7153 Gene denotes ACE2 Gene:59272
577 7308-7312 Gene denotes ACE2 Gene:59272
578 7043-7051 Species denotes SARS‐CoV Tax:694009
579 6959-6978 Chemical denotes oxazole‐carboxamide
587 7514-7522 Species denotes SARS‐CoV Tax:694009
588 7995-7999 Species denotes mice Tax:10090
589 8085-8093 Species denotes SARS‐CoV Tax:694009
590 8005-8014 Chemical denotes Quercetin MESH:D011794
591 7641-7653 Disease denotes cytotoxicity MESH:D064420
592 7800-7808 Disease denotes toxicity MESH:D064420
593 7568-7570 CellLine denotes E6 CVCL:4582
599 8180-8199 Gene denotes ADS‐J1 (5; Figure 4
600 8216-8224 Species denotes SARS‐CoV Tax:694009
601 8485-8488 Species denotes CoV Tax:11118
602 8418-8426 Chemical denotes Imatinib MESH:D000068877
603 8352-8374 Disease denotes SARS‐CoV‐1 S HR region MESH:C000657245
617 8901-8905 Gene denotes ACE2 Gene:59272
618 9090-9095 Gene denotes spike Gene:43740568
619 9097-9098 Gene denotes S Gene:43740568
620 9245-9249 Gene denotes ACE2 Gene:59272
621 9226-9227 Gene denotes S Gene:43740568
622 8694-8704 Species denotes SARS‐CoV‐2 Tax:2697049
623 8741-8749 Species denotes SARS‐CoV Tax:694009
624 8874-8882 Species denotes SARS‐CoV Tax:694009
625 9061-9071 Species denotes SARS‐CoV‐2 Tax:2697049
626 9113-9121 Species denotes SARS‐CoV Tax:694009
627 9189-9197 Species denotes SARS‐CoV Tax:694009
628 9215-9225 Species denotes SARS‐CoV‐2 Tax:2697049
629 8863-8872 Disease denotes infection MESH:D007239
649 9360-9363 Gene denotes ACE Gene:1636
650 9534-9538 Gene denotes ACE1 Gene:1636
651 9543-9547 Gene denotes ACE2 Gene:59272
652 9600-9604 Gene denotes ACE1 Gene:1636
653 9982-9985 Gene denotes ACE Gene:1636
654 9907-9915 Species denotes patients Tax:9606
655 9930-9938 Species denotes SARS‐CoV Tax:694009
656 9944-9954 Species denotes SARS‐CoV‐2 Tax:2697049
657 9473-9476 Chemical denotes Ang
658 9555-9567 Chemical denotes Ang peptides
659 9698-9707 Chemical denotes dipeptide MESH:D004151
660 9708-9711 Chemical denotes His MESH:D006639
661 9712-9715 Chemical denotes Leu MESH:D007930
662 9801-9813 Disease denotes inflammation MESH:D007249
663 9819-9827 Disease denotes fibrosis MESH:D005355
664 9844-9879 Disease denotes acute respiratory distress syndrome MESH:D012128
665 9881-9885 Disease denotes ARDS MESH:D012128
666 9891-9903 Disease denotes lung failure MESH:D012131
667 9916-9924 Disease denotes infected MESH:D007239
673 10141-10151 Gene denotes ACE1 and 2 Gene:1636
674 10277-10287 Gene denotes ACE1 and 2 Gene:1636
675 10291-10308 Gene denotes renin‐angiotensin
676 10317-10320 Gene denotes ACE Gene:1636
677 10322-10351 Gene denotes angiotensin‐converting enzyme Gene:1636
686 10407-10411 Gene denotes ACE2 Gene:59272
687 10522-10526 Gene denotes ACE1 Gene:1636
688 10632-10640 Gene denotes Ang (1–9 Gene:7108
689 10690-10694 Gene denotes ACE2 Gene:59272
690 10646-10654 Gene denotes Ang (1–7 Gene:7108
691 10572-10575 Chemical denotes Leu MESH:D007930
692 10579-10582 Chemical denotes Phe MESH:D010649
693 10750-10773 Disease denotes cardiovascular diseases MESH:D002318
697 10850-10854 Gene denotes ACE2 Gene:59272
698 10939-10978 Chemical denotes N‐(2‐aminoethyl)‐1 aziridine‐ethanamine
699 11076-11088 Disease denotes cytotoxicity MESH:D064420
705 11182-11186 Gene denotes ACE2 Gene:59272
706 11188-11191 Gene denotes ACE Gene:1636
707 11193-11222 Gene denotes angiotensin‐converting enzyme Gene:1636
708 11155-11163 Species denotes SARS‐CoV Tax:694009
709 11224-11232 Species denotes SARS‐CoV Tax:694009
716 11810-11814 Gene denotes IL‐6 Gene:3569
717 11280-11291 Chemical denotes Chloroquine MESH:D002738
718 11733-11744 Chemical denotes chloroquine MESH:D002738
719 11381-11388 Disease denotes malaria MESH:D008288
720 11393-11402 Disease denotes amebiasis MESH:D000562
721 11873-11877 Disease denotes ARDS MESH:D012128
735 12390-12394 Gene denotes ACE2 Gene:59272
736 12441-12445 Gene denotes ACE2 Gene:59272
737 11932-11940 Species denotes SARS‐CoV Tax:694009
738 11944-11952 Species denotes MERS‐CoV Tax:1335626
739 11958-11968 Species denotes SARS‐CoV‐2 Tax:2697049
740 11994-12004 Species denotes SARS‐CoV‐2 Tax:2697049
741 12076-12084 Species denotes SARS‐CoV Tax:694009
742 12375-12383 Species denotes SARS‐CoV Tax:694009
743 12480-12488 Species denotes SARS‐CoV Tax:694009
744 12193-12204 Species denotes respiratory Tax:12814
745 11882-11893 Chemical denotes Chloroquine MESH:D002738
746 12268-12279 Chemical denotes chloroquine MESH:D002738
747 12284-12304 Disease denotes SARS‐CoV‐1 infection MESH:C000657245
755 12508-12518 Species denotes SARS‐CoV‐2 Tax:2697049
756 12703-12711 Species denotes patients Tax:9606
757 12529-12540 Chemical denotes chloroquine MESH:D002738
758 12920-12941 Chemical denotes chloroquine phosphate MESH:C023676
759 12653-12661 Disease denotes COVID‐19 MESH:C000657245
760 12717-12730 Disease denotes heart disease MESH:D006331
761 12734-12742 Disease denotes diabetes MESH:D003920
764 12961-12979 Chemical denotes Hydroxychloroquine MESH:D006886
765 13044-13052 Disease denotes COVID‐19 MESH:C000657245
781 13164-13174 Species denotes SARS‐CoV‐2 Tax:2697049
782 13347-13358 Species denotes Ebola virus Tax:1570291
783 13466-13474 Species denotes patients Tax:9606
784 13825-13833 Species denotes patients Tax:9606
785 13951-13959 Species denotes patients Tax:9606
786 14088-14096 Species denotes patients Tax:9606
787 13124-13142 Chemical denotes Hydroxychloroquine MESH:D006886
788 13261-13279 Chemical denotes hydroxychloroquine MESH:D006886
789 13284-13296 Chemical denotes azithromycin MESH:D017963
790 13298-13310 Chemical denotes Azithromycin MESH:D017963
791 13540-13558 Chemical denotes hydroxychloroquine MESH:D006886
792 13602-13614 Chemical denotes azithromycin MESH:D017963
793 13728-13746 Chemical denotes hydroxychloroquine MESH:D006886
794 13797-13809 Chemical denotes azithromycin MESH:D017963
795 13490-13506 Disease denotes viral infections MESH:D001102
801 14478-14486 Species denotes patients Tax:9606
802 14202-14213 Chemical denotes chloroquine MESH:D002738
803 14233-14251 Chemical denotes hydroxychloroquine MESH:D006886
804 14351-14359 Disease denotes COVID‐19 MESH:C000657245
805 14469-14477 Disease denotes COVID‐19 MESH:C000657245
822 14534-14542 Species denotes patients Tax:9606
823 14799-14807 Species denotes patients Tax:9606
824 14864-14872 Species denotes patients Tax:9606
825 14610-14628 Chemical denotes hydroxychloroquine MESH:D006886
826 14632-14643 Chemical denotes chloroquine MESH:D002738
827 14686-14695 Chemical denotes macrolide MESH:D018942
828 14704-14716 Chemical denotes azithromycin MESH:D017963
829 14721-14735 Chemical denotes clarithromycin MESH:D017291
830 15112-15123 Chemical denotes chloroquine MESH:D002738
831 15128-15146 Chemical denotes hydroxychloroquine MESH:D006886
832 15312-15330 Chemical denotes hydroxychloroquine MESH:D006886
833 14548-14556 Disease denotes COVID‐19 MESH:C000657245
834 14909-14931 Disease denotes ventricular arrhythmia MESH:D001145
835 15073-15081 Disease denotes COVID‐19 MESH:C000657245
836 15202-15221 Disease denotes autoimmune diseases MESH:D001327
837 15226-15233 Disease denotes malaria MESH:D008288
851 15409-15413 Gene denotes ACE2 Gene:59272
852 15504-15539 Gene denotes A disintegrin and metalloproteinase
853 15541-15545 Gene denotes ADAM
854 15562-15585 Gene denotes TNF‐α converting enzyme Gene:6868
855 15587-15591 Gene denotes TACE Gene:6868
856 15630-15634 Gene denotes ACE2 Gene:59272
857 15689-15693 Gene denotes ACE2 Gene:59272
858 15785-15789 Gene denotes ACE2 Gene:59272
859 15807-15811 Gene denotes TACE Gene:6868
860 15871-15875 Gene denotes ACE2 Gene:59272
861 15695-15704 Chemical denotes GW280264X MESH:C492546
862 15824-15830 Chemical denotes TAPI‐0
863 15840-15846 Chemical denotes TAPI‐2 MESH:C099410
868 15999-16003 Gene denotes ACE2 Gene:59272
869 16124-16128 Gene denotes ACE2 Gene:59272
870 16118-16123 Species denotes human Tax:9606
871 16194-16204 Species denotes SARS‐CoV‐2 Tax:2697049
877 16470-16474 Gene denotes ACE2 Gene:59272
878 16759-16769 Species denotes SARS‐CoV‐2 Tax:2697049
879 16609-16618 Species denotes influenza Tax:11309
880 16527-16537 Chemical denotes Umifenovir MESH:C086979
881 16554-16561 Chemical denotes Arbidol MESH:C086979
893 16883-16887 Gene denotes ACE2 Gene:59272
894 17174-17178 Gene denotes ACE2 Gene:59272
895 17283-17287 Gene denotes ACE2 Gene:59272
896 16805-16815 Species denotes SARS‐CoV‐2 Tax:2697049
897 16910-16920 Species denotes SARS‐CoV‐2 Tax:2697049
898 17037-17045 Species denotes patients Tax:9606
899 17102-17110 Species denotes patients Tax:9606
900 17196-17204 Species denotes patients Tax:9606
901 16867-16875 Disease denotes COVID‐19 MESH:C000657245
902 17028-17036 Disease denotes COVID‐19 MESH:C000657245
903 17210-17223 Disease denotes heart disease MESH:D006331
908 17515-17519 Gene denotes ACE2 Gene:59272
909 17623-17627 Gene denotes ACE2 Gene:59272
910 17460-17468 Species denotes patients Tax:9606
911 17568-17576 Disease denotes COVID‐19 MESH:C000657245
913 17686-17689 Disease denotes AHA
916 17971-17979 Species denotes SARS‐CoV Tax:694009
917 18116-18129 Disease denotes lung diseases MESH:D008171
919 18174-18178 Species denotes CoVs Tax:11118
924 18756-18760 Gene denotes ACE2 Gene:59272
925 18808-18813 Gene denotes CD147 Gene:682
926 18394-18397 Species denotes CoV Tax:11118
927 18761-18771 Species denotes SARS‐CoV‐2 Tax:2697049
938 18982-18993 Gene denotes cathepsin L Gene:1514
939 18995-19002 Gene denotes TMPRSS2 Gene:7113
940 19308-19315 Gene denotes TMPRSS2 Gene:7113
941 19381-19386 Gene denotes Furin Gene:103231185
942 18899-18902 Species denotes CoV Tax:11118
943 19421-19429 Species denotes MERS‐CoV Tax:1335626
944 19390-19396 Chemical denotes serine MESH:D012694
945 19256-19270 Disease denotes CoV infections MESH:D018352
946 19344-19363 Disease denotes SARS‐CoV‐2‐infected MESH:C000657245
947 19364-19370 CellLine denotes VeroE6 CVCL:0574
960 19631-19639 Species denotes MERS‐CoV Tax:1335626
961 19644-19652 Species denotes SARS‐CoV Tax:694009
962 19804-19809 Species denotes human Tax:9606
963 19810-19813 Species denotes CoV Tax:11118
964 19820-19837 Species denotes hepatitis C virus Tax:11103
965 19839-19866 Species denotes infectious bronchitis virus Tax:11120
966 19879-19900 Species denotes mouse hepatitis virus Tax:11138
967 19814-19818 Species denotes 229E Tax:11137
968 19533-19547 Chemical denotes chlorpromazine MESH:D002746
969 19554-19566 Chemical denotes promethazine MESH:D011398
970 19577-19589 Chemical denotes fluphenazine MESH:D005476
971 19712-19726 Chemical denotes Chlorpromazine MESH:D002746
978 20165-20172 Gene denotes TMPRSS2 Gene:7113
979 20484-20510 Gene denotes EST (a cathepsin inhibitor Gene:6783
980 20134-20142 Species denotes SARS‐CoV Tax:694009
981 20267-20275 Species denotes SARS‐CoV Tax:694009
982 20076-20082 Chemical denotes serine MESH:D012694
983 20550-20559 Disease denotes infection MESH:D007239
987 20635-20642 Gene denotes TMPRSS2 Gene:7113
988 20644-20650 Gene denotes TMPRSS Gene:3003
989 20666-20672 Chemical denotes serine MESH:D012694
994 20749-20759 Species denotes SARS‐CoV‐2 Tax:2697049
995 20923-20931 Species denotes SARS‐CoV Tax:694009
996 20872-20893 Gene denotes a cathepsin inhibitor Gene:6783
997 20865-20870 Chemical denotes E‐64d
1002 21078-21095 Gene denotes cysteine protease Gene:1508
1003 21357-21364 Gene denotes TMPRSS2 Gene:7113
1004 21147-21155 Species denotes SARS‐CoV Tax:694009
1005 21162-21170 Species denotes MERS‐CoV Tax:1335626
1020 21654-21665 Gene denotes cathepsin L Gene:1514
1021 21489-21510 Species denotes Staphylococcus aureus Tax:1280
1022 21515-21536 Species denotes Enterococcus faecalis Tax:1351
1023 21590-21598 Species denotes SARS‐CoV Tax:694009
1024 21602-21610 Species denotes MERS‐CoV Tax:1335626
1025 21616-21627 Species denotes Ebola virus Tax:1570291
1026 21732-21742 Species denotes SARS‐CoV‐2 Tax:2697049
1027 21366-21377 Chemical denotes Teicoplanin MESH:D017334
1028 21383-21395 Chemical denotes glycopeptide MESH:D006020
1029 21467-21478 Chemical denotes methicillin MESH:D008712
1030 21556-21567 Chemical denotes teicoplanin MESH:D017334
1031 21799-21810 Chemical denotes teicoplanin MESH:D017334
1032 21423-21433 Disease denotes infections MESH:D007239
1033 21874-21882 Disease denotes COVID‐19 MESH:C000657245
1035 21913-21924 Gene denotes cathepsin L Gene:1514
1042 21942-21953 Gene denotes cathepsin L Gene:1514
1043 21936-21941 Species denotes Human Tax:9606
1044 22293-22301 Chemical denotes MDL28170 MESH:C058076
1045 22007-22016 Disease denotes infection MESH:D007239
1046 22249-22262 Disease denotes CoV infection MESH:D018352
1047 22531-22543 Disease denotes cytotoxicity MESH:D064420
1049 22594-22605 Gene denotes Cathepsin L Gene:1514
1062 22758-22769 Gene denotes cathepsin L Gene:1514
1063 22812-22823 Gene denotes cathepsin L Gene:1514
1064 22744-22752 Species denotes SARS‐CoV Tax:694009
1065 22987-22992 Species denotes human Tax:9606
1066 23073-23078 Species denotes human Tax:9606
1067 22665-22668 Disease denotes CID
1068 22687-22690 Disease denotes CID
1069 22953-22968 Disease denotes virus infection MESH:D001102
1070 22993-23009 Disease denotes embryonic kidney MESH:D007674
1071 23061-23069 Disease denotes toxicity MESH:D064420
1072 23187-23209 Disease denotes Ebola virus infections MESH:D019142
1073 23010-23014 CellLine denotes 293T CVCL:0063
1077 23302-23364 Gene denotes SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase
1078 23487-23499 Disease denotes cytotoxicity MESH:D064420
1079 23428-23432 CellLine denotes 293T CVCL:0063
1087 24020-24024 Gene denotes ACE2 Gene:59272
1088 23930-23951 Species denotes Polygonum multiflorum Tax:76025
1089 23956-23972 Species denotes Rheum officinale Tax:137220
1090 23881-23887 Chemical denotes emodin MESH:D004642
1091 24283-24292 Chemical denotes benzamide MESH:C037689
1092 23856-23862 Disease denotes Hsiang
1093 24138-24140 CellLine denotes E6 CVCL:4582
1100 24778-24787 Gene denotes Cathepsin
1101 24603-24611 Species denotes SARS‐CoV Tax:694009
1102 24721-24729 Species denotes SARS‐CoV Tax:694009
1103 24818-24826 Species denotes MERS‐CoV Tax:1335626
1104 24798-24804 Chemical denotes E‐64‐D
1105 24831-24851 Disease denotes SARS‐CoV‐1 infection MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T117 0-25 Sentence denotes 2 VIRUS ENTRY INHIBITORS
T118 26-203 Sentence denotes Binding of spike protein (S) to its receptor represents the host's first confrontation with the virus and its life cycle, thus providing prophylactic intervention opportunities.
T119 204-343 Sentence denotes The genome of SARS‐CoV‐2 has been recently determined to have an 80% identity to that of SARS‐CoV‐1 and 96% identity to the bat‐CoV RaTG13.
T120 344-464 Sentence denotes 26 The SARS‐CoV‐2 S protein shows nucleotide sequence identities of 75% or less to all other previously described CoVs.
T121 465-561 Sentence denotes However, again, the new SARS‐CoV‐2 S protein shares a 93.1% identity to the S protein of RaTG13.
T122 562-841 Sentence denotes SARS‐CoV‐2 spike (S) recognizes, with its receptor‐binding domain (RBD), the cellular ACE2 receptor with high affinity (K d, 14.7 nM) 27 as judged by surface plasmin resonance spectrometry; and intervention at the RBD‐ACE2 interface can potentially disrupt infection efficiency.
T123 842-954 Sentence denotes It was observed that the RBDs of the SARS‐CoV‐2‐ACE2 and SARS‐CoV‐1‐ACE2 complexes are quite similar (Figure 3).
T124 955-957 Sentence denotes 29
T125 958-1130 Sentence denotes Figure 3 Comparison of the SARS‐CoV‐2 S and SARS‐CoV‐1 S structures: ribbon diagrams of the (A) SARS‐CoV‐2 S and (D) SARS‐CoV‐1 S [PDB 6NB6] ectodomain cryo‐EM structures.
T126 1131-1184 Sentence denotes S1 subunits of (B) SARS‐CoV‐2 S and (E) SARS‐CoV‐1 S.
T127 1185-1238 Sentence denotes S2 subunits of (C) SARS‐CoV‐2 S and (F) SARS‐CoV‐1 S.
T128 1239-1435 Sentence denotes 28 cryo‐EM, cryogenic electron microscopy; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2 [Color figure can be viewed at wileyonlinelibrary.com] As mentioned previously, Zhang et al.
T129 1436-1602 Sentence denotes 30 determined the full‐length genome sequence of SARS‐CoV‐2 and revealed that the virus is remarkably similar (89.1% sequence identity) to a group of SARS‐like CoVs.
T130 1603-1629 Sentence denotes Simultaneously, Shi et al.
T131 1630-1819 Sentence denotes 26 reported that SARS‐CoV‐2 shares 96% sequence identity at a whole‐genome level with a bat coronavirus—and importantly, like SARS‐CoV‐1, SARS‐CoV‐2 utilizes ACE2 receptor for viral entry.
T132 1820-2011 Sentence denotes Recently, Yan et al. solved the cryo‐EM structure of full‐length human ACE2 bound to the RBD of SARS‐CoV‐2, providing important structural information for therapeutic intervention strategies.
T133 2012-2014 Sentence denotes 29
T134 2015-2119 Sentence denotes The sequence identity of the spike protein between SARS‐CoV‐1 (1273 aa) and SARS‐CoV‐2 (1253 aa) is 76%.
T135 2120-2165 Sentence denotes The spike protein has two regions, S1 and S2.
T136 2166-2256 Sentence denotes The S1 region of the SARS‐CoV‐1 has a RBD that forms high‐affinity interactions with ACE2.
T137 2257-2359 Sentence denotes The prevailing understanding is that SARS‐CoV‐2 employs this RBD to enter its human host cell as well.
T138 2360-2430 Sentence denotes Aligning the two different RBDs revealed a sequence identity of 73.5%.
T139 2431-2543 Sentence denotes However, many nonconserved mutations that interact directly with ACE2 are located in the two structural regions.
T140 2544-2735 Sentence denotes 31 And both crystal and cryo‐EM structures of the SARS‐CoV‐1 spike‐ACE2 complex have shown that merely residues of regions 1 and 2 form hydrogen bonds and hydrophobic interactions with ACE2.
T141 2736-2849 Sentence denotes The mutations in these two regions of SARS‐CoV‐2 will, therefore, likely reduce the number of those interactions.
T142 2850-2852 Sentence denotes 32
T143 2853-2960 Sentence denotes Studies also have shown that the RdRP, and the Mpro are highly conserved between SARS‐CoV‐2 and SARS‐CoV‐1.
T144 2961-3095 Sentence denotes 33 , 34 Therefore, it is widely accepted that SARS‐CoV‐2 behaves similarly to SARS‐CoV‐1 with regard to viral entry and replication.
T145 3096-3272 Sentence denotes Since the general genomic layout and replication kinetics are so conserved among MERS, SARS‐1, and SARS‐2 CoVs, investigating inhibitors of common structures is a logical step.
T146 3273-3455 Sentence denotes The inhibitory strength against viral enzyme was expressed as IC50, which is the concentration of the inhibitor needed to inhibit half of the enzyme activity in the tested condition.
T147 3456-3525 Sentence denotes The K i value is reflective of ligand‐binding affinity to the enzyme.
T148 3526-3688 Sentence denotes The inhibitory activity for cell‐based bioassays is expressed as EC50, which is a half maximal effective concentration required to induce the biological response.
T149 3689-3857 Sentence denotes The warhead group means a “reactive group” of the inhibitors that can form both covalent and noncovalent interactions with amino acids in the active site of the enzyme.
T150 3859-3881 Sentence denotes 2.1 Targeting the RBD
T151 3882-3994 Sentence denotes Structural investigations of the RBD‐ACE2 complex provided information about essential residues for viral entry.
T152 3995-4008 Sentence denotes Hsiang et al.
T153 4009-4148 Sentence denotes 35 reported a number of peptides that significantly blocked the interaction of the S protein with ACE2 with IC50 values as low as 1.88 nM.
T154 4149-4250 Sentence denotes Michael et al. found charged residues between positions 22 and 57 crucial for SARS‐CoV‐1 viral entry.
T155 4251-4384 Sentence denotes Based on this, they designed peptides P4 (IC50, 50 µM) and P5 (IC50, 6.0 µM) with significant inhibitory activity against SARS‐CoV‐1.
T156 4385-4653 Sentence denotes The antiviral activity was further improved when they introduced the glycine binding linkage of peptide P4 (residues 22–47) with an ACE2‐derived peptide (residues 351–357) against a SARS‐CoV‐1 pseudovirus with an IC50 of 100 nM and devoid of cytotoxicity up to 200 µM.
T157 4654-4741 Sentence denotes 36 It is worth highlighting that a similar strategy could work for the new SARS‐CoV‐2.
T158 4742-4879 Sentence denotes The recently solved cryo‐EM structure of SARS‐CoV‐2 in complex with human ACE2 can provide a structural rationale for the peptide design.
T159 4880-4882 Sentence denotes 29
T160 4883-5056 Sentence denotes For viral entry, MERS‐CoV uses its spike protein (S) to interact with the host‐receptor DPP4, 37 , 38 , 39 also known as adenosine deaminase‐complexing protein‐2 or CD26.
T161 5057-5132 Sentence denotes 37 MERS‐CoV was also the first virus reported to use this particular path.
T162 5133-5281 Sentence denotes 35 , 37 DPP4 is a type II transmembrane glycoprotein, that forms homodimers on the cell surface, and it is involved in the cleavage of dipeptides.
T163 5282-5397 Sentence denotes 37 , 40 In humans, DPP4 is predominantly found on the bronchial epithelial and alveolar cells in the lower lungs.
T164 5398-5406 Sentence denotes 40 , 41
T165 5407-5557 Sentence denotes MERS‐4 and MERS‐27 are monoclonal antibodies targeting the RBD of MERS‐CoV S that were discovered in a nonimmune yeast‐display scFv library screening.
T166 5558-5689 Sentence denotes The more active MERS‐4 potently blocked the infection of DPP4‐expressing Huh‐7 cells with pseudotyped MERS‐CoV (IC50, 0.056 μg/mL).
T167 5690-5797 Sentence denotes It also prevented MERS‐CoV‐induced cytopathogenic effects in MERS‐infected Vero E6 cells (IC50, 0.5 μg/mL).
T168 5798-5800 Sentence denotes 42
T169 5801-5877 Sentence denotes A heptad repeat (HR) is a repeating structural pattern of seven amino acids.
T170 5878-6008 Sentence denotes A crucial membrane fusion framework of SARS‐CoV is the 6‐helix‐bundle (6‐HB) that is formed by HR1 and HR2 of the viral S protein.
T171 6009-6094 Sentence denotes Enfuvirtide (T‐20) is an FDA approved HR2 peptide and the first HIV fusion inhibitor.
T172 6095-6193 Sentence denotes It has opened up new avenues toward identifying and developing peptides as viral entry inhibitors.
T173 6194-6464 Sentence denotes Such molecules represent a promising strategy against enveloped viruses with class 1 fusion proteins such as Nipah virus, Hendra virus, Ebola virus, and other paramyxoviruses, simian immunodeficiency virus, feline immunodeficiency virus, and respiratory syncytial virus.
T174 6465-6664 Sentence denotes 43 , 44 , 45 , 46 The HR regions of SARS‐CoV‐1 and SARS‐CoV‐2 S protein share a high degree of conservation, and such fusion inhibitors have potential applications in preventing SARS‐CoV‐2 entry.
T175 6665-6748 Sentence denotes Small molecule entry inhibitors, on the other hand, are reported to target the RBD.
T176 6749-6925 Sentence denotes Compared to peptides, proteins, and biologics, small molecules have several advantages due to lower production costs, improved pharmacokinetics, stability, and dosage accuracy.
T177 6926-7113 Sentence denotes Sarafianos et al. identified the oxazole‐carboxamide derivative SSAA09E2 (1; Figure 4) as an entry inhibitor against SARS‐CoV‐1 by screening a chemical library composed of 3000 compounds.
T178 7114-7331 Sentence denotes 47 This inhibitor directly blocks ACE2 recognition by interfering with the RBD with an EC50 value of 3.1 µM and a 50% cytotoxic concentration (CC50) value of greater than 100 µM, not affecting ACE2 expression levels.
T179 7332-7334 Sentence denotes 48
T180 7335-7403 Sentence denotes Figure 4 Inhibitors targeting the receptor‐binding domain Xu et al.
T181 7404-7583 Sentence denotes 49 identified two small molecules, TGG (2; Figure 4) and luteolin (3; Figure 4), that can bind avidly to the SARS‐CoV‐1 S2 protein and inhibit its entry into Vero E6 cells (EC50:
T182 7584-7615 Sentence denotes 4.5 µM, 10.6 µM; respectively).
T183 7616-7767 Sentence denotes Compounds 2 and 3 showed cytotoxicity (CC50) of 1.08 and 0.155 mM, and the selectivity index (SI) values of 2 and 3 were 240.0 and 14.62, respectively.
T184 7768-7893 Sentence denotes Further studies regarding acute toxicity revealed that the 50% lethal doses of 2 and 3 were ~456 and 232 mg/kg, respectively.
T185 7894-8000 Sentence denotes These results indicate that these small molecules could be used at relatively high concentrations in mice.
T186 8001-8155 Sentence denotes 49 Quercetin (4; Figure 4), an analog of 3, also showed antiviral activity against SARS‐CoV‐1, with an EC50 value of 83.4 µM and a CC50 value of 3.32 mM.
T187 8156-8158 Sentence denotes 50
T188 8159-8273 Sentence denotes Ngai et al. reported ADS‐J1 (5; Figure 4) as a potential SARS‐CoV‐1 viral entry inhibitor with an EC50 of 3.89 µM.
T189 8274-8413 Sentence denotes Molecular docking studies predicted that 5 can bind into a deep pocket of the SARS‐CoV‐1 S HR region and block viral entry into host cells.
T190 8414-8615 Sentence denotes 51 Imatinib (6; Figure 4), an Abelson kinase inhibitor, could inhibit CoV S protein‐induced fusion with an EC50 value of 10 µM and showed no cytotoxic effects in Vero cells up to 100 µM concentration.
T191 8616-8624 Sentence denotes 52 , 53
T192 8626-8673 Sentence denotes 2.2 Inhibitors targeting the cellular receptor
T193 8674-8792 Sentence denotes The genetic code of SARS‐CoV‐2 shares noticeable similarities with SARS‐CoV‐1, which caused the SARS epidemic in 2002.
T194 8793-8873 Sentence denotes 26 , 54 More importantly, both viruses have identical mechanisms of infection.
T195 8874-9056 Sentence denotes SARS‐CoV‐1 uses the host's ACE2 as a portal to infect cells, which has high expression in the vascular endothelium 55 and the lung, particularly in type 2 alveolar epithelial cells.
T196 9057-9124 Sentence denotes 56 SARS‐CoV‐2 shares 76% of its spike (S) protein with SARS‐CoV‐1.
T197 9125-9359 Sentence denotes Despite a few amino acid differences in its RBD compared to the SARS‐CoV‐1 S protein, the SARS‐CoV‐2 S protein binds to ACE2 with even greater affinity 27 offering an explanation for its greater virulence and preference for the lung.
T198 9360-9528 Sentence denotes ACE, a highly glycosylated type I integral membrane protein, is an essential component of the renin‐angiotensin (Ang) system, which controls blood pressure homeostasis.
T199 9529-9568 Sentence denotes Both ACE1 and ACE2 cleave Ang peptides.
T200 9569-9716 Sentence denotes However, they differ markedly: ACE1 cuts and converts the inactive decapeptide Ang I into the octapeptide Ang II by removing the dipeptide His‐Leu.
T201 9717-9970 Sentence denotes This Ang II induces vaso‐ and bronchoconstriction, increased vascular permeability, inflammation, and fibrosis, thus promoting acute respiratory distress syndrome (ARDS) and lung failure in patients infected with SARS‐CoV‐1 or SARS‐CoV‐2 57 (Figure 5).
T202 9971-10102 Sentence denotes Therefore, ACE‐inhibitors (ACEis) and angiotensin II receptor blockers (ARBs) could block the disease‐propagating effect of Ang II.
T203 10103-10117 Sentence denotes 58 , 59 , 60
T204 10118-10184 Sentence denotes Figure 5 The roles of ACE1 and 2 in the renin‐angiotensin system.
T205 10185-10316 Sentence denotes A, Chemical structures of angiotensin‐related peptides and B, Schematic diagram of roles of ACE1 and 2 in renin‐angiotensin system.
T206 10317-10527 Sentence denotes ACE, angiotensin‐converting enzyme [Color figure can be viewed at wileyonlinelibrary.com] ACE2, on the other hand, is a zinc‐containing metalloenzyme, and shares merely 42% of its amino acid sequence with ACE1.
T207 10528-10683 Sentence denotes 61 It cleaves only one amino acid residue (Leu or Phe) from Ang I and Ang II, respectively, generating Ang (1–9) and Ang (1–7) (a vasodilator) (Figure 5).
T208 10684-10774 Sentence denotes Thus, ACE2 has been considered a potential therapeutic target for cardiovascular diseases.
T209 10775-11041 Sentence denotes Virtual screening combined with a molecular docking approach targeting the ACE2 catalytic site with around 140 000 compounds led to the identification of inhibitor N‐(2‐aminoethyl)‐1 aziridine‐ethanamine (7; Figure 6) with an IC50 value of 57 µM and a K i of 459 µM.
T210 11042-11126 Sentence denotes However, no information about the cytotoxicity of this compound is available so far.
T211 11127-11129 Sentence denotes 62
T212 11130-11187 Sentence denotes Figure 6 Inhibitors for SARS‐CoV‐1 and 2 targeting ACE2.
T213 11188-11403 Sentence denotes ACE, angiotensin‐converting enzyme; SARS‐CoV, severe acute respiratory syndrome coronavirus Chloroquine (8; Figure 6) is a relatively safe, cheap, and effective medication for the treatment of malaria and amebiasis.
T214 11404-11419 Sentence denotes Savarino et al.
T215 11420-11455 Sentence denotes 63 reported its antiviral effects.
T216 11456-11596 Sentence denotes At a molecular level, it increases late endosomal and lysosomal pH, resulting in impaired liberation of virions from endosomes or lysosomes.
T217 11597-11687 Sentence denotes The virus is therefore unable to release its genetic material into the cell and replicate.
T218 11688-11878 Sentence denotes 64 , 65 Furthermore, they hypothesize that chloroquine might block the production of proinflammatory cytokines (such as IL‐6), thereby blocking the pathway that subsequently leads to ARDS.
T219 11879-11881 Sentence denotes 63
T220 11882-11969 Sentence denotes Chloroquine is reasonably active in vitro against SARS‐CoV‐1, MERS‐CoV, and SARS‐CoV‐2.
T221 11970-12044 Sentence denotes It was found to inhibit SARS‐CoV‐2 with an EC50 value of 5.47 µM in vitro.
T222 12045-12234 Sentence denotes 66 Antiviral activity against SARS‐CoV‐1 was reported with an IC50 of 8.8 μM in Vero cells, but it is unclear how this translates into activity in respiratory epithelial cells and in vivo.
T223 12235-12493 Sentence denotes 67 , 68 Mechanistic studies of chloroquine for SARS‐CoV‐1 infection revealed that it could also weaken the interaction between the RBD of SARS‐CoV‐1 and ACE2 by interfering with terminal glycosylation of ACE2, thereby reducing its affinity to SARS‐CoV‐1 S.
T224 12494-12496 Sentence denotes 69
T225 12497-12743 Sentence denotes During the SARS‐CoV‐2 pandemic, chloroquine has been recommended by Chinese, South Korean, and Italian health authorities for the experimental treatment of COVID‐19, 70 , 71 despite contraindications for patients with heart disease or diabetes.
T226 12744-12960 Sentence denotes 72 However, health experts and agencies like the US FDA and European Medicines Agency warned against broad uncontrolled use after reports of misuse of low‐quality versions of chloroquine phosphate intended for fish.
T227 12961-13053 Sentence denotes Hydroxychloroquine (9; Figure 6) is being studied as an experimental treatment for COVID‐19.
T228 13054-13120 Sentence denotes 73 However, the benefits of treatment with this drug are unclear.
T229 13121-13123 Sentence denotes 74
T230 13124-13214 Sentence denotes Hydroxychloroquine was found to inhibit SARS‐CoV‐2 with an EC50 value of 0.74 µM in vitro.
T231 13215-13297 Sentence denotes 66 Some studies imply synergistic effects of hydroxychloroquine and azithromycin.
T232 13298-13507 Sentence denotes Azithromycin is active in vitro against Zika and Ebola virus 75 , 76 and can be used to guard against life‐threatening bacterial superinfections when administered to patients suffering from viral infections.
T233 13508-13664 Sentence denotes 77 A small study that compared hydroxychloroquine monotherapy and combination treatment with azithromycin found a significant advantage of the combination.
T234 13665-14062 Sentence denotes While evaluating the efficacy of therapeutic intervention with hydroxychloroquine as monotherapy and its impact in combination with azithromycin, the number of patients testing negative in polymerase chain reaction (PCR) tests was substantially different in the two groups with 100% of patients cured (6 days post inclusion) in the combination arm of the study versus 57% in the monotherapy group.
T235 14063-14158 Sentence denotes At the same time, 12% of patients in the control group receiving only standard care were cured.
T236 14159-14167 Sentence denotes 78 , 79
T237 14168-14360 Sentence denotes The WHO declared on 18 March that chloroquine and its derivative hydroxychloroquine will be among the four medicines studied in the solidarity clinical trial 80 for the treatment of COVID‐19.
T238 14361-14487 Sentence denotes In April 2020, the US National Institutes of Health (NIH) also commenced a study with the drug for treating COVID‐19 patients.
T239 14488-14490 Sentence denotes 81
T240 14491-14737 Sentence denotes The recent clinical trial involving 96 032 patients with COVID‐19 concluded that it was unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or in combination with a macrolide such as azithromycin (or clarithromycin).
T241 14738-14849 Sentence denotes 82 The study actually reported decreased survival rates for patients treated with each of these drug regimens.
T242 14850-14948 Sentence denotes Additionally, patients had an increased risk of developing ventricular arrhythmia under treatment.
T243 14949-15235 Sentence denotes However, still more evidence is needed to adequately assess the drugs' risks or benefits for the treatment or prevention of COVID‐19 (it is important to note that chloroquine and hydroxychloroquine are still considered safe treatment options in certain autoimmune diseases and malaria).
T244 15236-15369 Sentence denotes Besides, the WHO announced the premature pause of its clinical trials using hydroxychloroquine as a safety precaution on 24 May 2020.
T245 15370-15499 Sentence denotes On a different note, it was found that ACE2 undergoes proteolytic shedding; releasing an enzymatic ectodomain during viral entry.
T246 15500-15635 Sentence denotes 83 A disintegrin and metalloproteinase (ADAM), also known as TNF‐α converting enzyme (TACE), assisted the shedding regulation of ACE2.
T247 15636-15694 Sentence denotes Inhibition of this enzyme led to reduced shedding of ACE2.
T248 15695-15798 Sentence denotes GW280264X (10; Figure 6) was found to be a specific inhibitor of ADAM‐induced shedding of ACE2 at 1 nM.
T249 15799-15935 Sentence denotes 84 Two TACE inhibitors, TAPI‐0 (11) and TAPI‐2 (12; Figure 6), reduced ACE2 shedding, with IC50 values of 100 and 200 nM, respectively.
T250 15936-15938 Sentence denotes 83
T251 15939-16034 Sentence denotes MLN‐4760 (13; Figure 6) inhibited the catalytic activity of ACE2 with an IC50 of around 440 pM.
T252 16035-16218 Sentence denotes 85 This is the most potent and selective small‐molecule inhibitor against soluble human ACE2 described to date, thus making it a very promising candidate for SARS‐CoV‐2 interference.
T253 16219-16294 Sentence denotes It binds to the active site zinc and emulates the transition state peptide.
T254 16295-16366 Sentence denotes However, no antiviral data for this compound is available at this time.
T255 16367-16526 Sentence denotes The interference of a virus‐host cell fusion, which is mediated by the viral S protein to its receptor ACE2 on host cells, may be a viable prevention strategy.
T256 16527-16678 Sentence denotes Umifenovir (14; brand name Arbidol), a broad spectrum antiviral drug used against influenza, prevents viral entry by inhibiting virus‐host cell fusion.
T257 16679-16770 Sentence denotes 86 It is currently being investigated in a clinical trial for the treatment of SARS‐CoV‐2.
T258 16771-16779 Sentence denotes 87 , 88
T259 16780-16876 Sentence denotes Do ACEis or ARBs amplify SARS‐CoV‐2 pathogenicity and aggravate the clinical course of COVID‐19?
T260 16877-17046 Sentence denotes After ACE2 was recognized as the SARS‐CoV‐2 receptor, 14 , 29 speculations emerged about potentially negative consequences of ACEi or ARB therapy in COVID‐19 patients.
T261 17047-17134 Sentence denotes This theory caused confusion in the public and alarmed patients taking these medicines.
T262 17135-17256 Sentence denotes One report said that the expression of ACE2 was increased in patients with heart disease compared to healthy individuals.
T263 17257-17418 Sentence denotes It was also insisted that ACE2 expression could be increased by taking ACEis and ARBs, 89 although there is no supporting report of this happening in the lungs.
T264 17419-17628 Sentence denotes In another report, it was suggested that patients suffering from high blood pressure receiving “ACE2‐increasing drugs” have a higher risk for severe COVID‐19, since ACEis and ARBs could elevate levels of ACE2.
T265 17629-17631 Sentence denotes 90
T266 17632-17860 Sentence denotes A joint declaration by the presidents of the HFSA/ACC/AHA on 17 March 2020, 91 followed by a similar statement of the European Medicines Agency, 92 clarified that there was no scientific basis for stopping ACEi or ARB therapy.
T267 17861-17956 Sentence denotes 93 , 94 , 95 This was in accordance with the editors of the New England Journal of Medicine.
T268 17957-17959 Sentence denotes 96
T269 17960-18130 Sentence denotes In case of SARS‐CoV, the experimental data showed that such medications may be beneficial rather than damaging, which led to a new therapeutic approach for lung diseases.
T270 18131-18133 Sentence denotes 97
T271 18135-18173 Sentence denotes 2.3 Proteolytic processing inhibitors
T272 18174-18330 Sentence denotes CoVs enter the host cells via both clathrin (endosomal) and nonclathrin pathways (nonendosomal); however, both pathways are dependent upon receptor binding.
T273 18331-18339 Sentence denotes 98 , 99
T274 18340-18505 Sentence denotes The clathrin‐mediated pathway involves the binding of CoV S protein to the host receptor followed by the internalization of vesicles that maturate to late endosomes.
T275 18506-18713 Sentence denotes Acidification of the endosome promotes the H+‐dependent activation of cellular cathepsin L proteinase in late endosomes and lysosomes, which cleaves and activates the S protein, thus initiating viral fusion.
T276 18714-18845 Sentence denotes Recent research shows that in addition to ACE2 SARS‐CoV‐2 can also use the host cell receptor CD147 to gain access into host cells.
T277 18846-18849 Sentence denotes 100
T278 18850-19140 Sentence denotes Membrane fusion is also the crucial step for the CoV life cycle in the nonclathrin/endosomal route, in which host proteases such as cathepsin L, TMPRSS2, and TMPRSS11D (airway trypsin‐like protease) cut the S protein at the S1/S2 cleavage site to activate the S protein for membrane fusion.
T279 19141-19271 Sentence denotes 101 Interference with this process by targeting these proteases could become an attractive strategy for combating CoV infections.
T280 19272-19377 Sentence denotes A recent study confirms the role of TMPRSS2 for the viral life cycle in SARS‐CoV‐2‐infected VeroE6 cells.
T281 19378-19489 Sentence denotes 5 Furin (a serine endoprotease) activates MERS‐CoV to initiate the nonclathrin mediated membrane fusion event.
T282 19490-19493 Sentence denotes 102
T283 19494-19706 Sentence denotes The neurotransmitter receptor blockers chlorpromazine (15), promethazine (16), and fluphenazine (17; Figure 7), were reported to inhibit MERS‐CoV and SARS‐CoV‐1 most probably by impeding S protein‐induced fusion.
T284 19707-19910 Sentence denotes 103 Chlorpromazine, a clathrin‐mediated viral entry inhibitor, was already described to inhibit human CoV‐229E, hepatitis C virus, infectious bronchitis virus, as well as mouse hepatitis virus‐2 (MHV2).
T285 19911-19942 Sentence denotes 104 , 105 , 106 , 107 , 108
T286 19943-20191 Sentence denotes Figure 7 Neurotransmitter inhibitors targeting clathrin/nonclathrin pathways Matsuyama et al. identified the commercially available serine protease inhibitor camostat (18; Figure 8) to be a SARS‐CoV‐1 inhibitor, blocking TMPRSS2 activity at 10 µM.
T287 20192-20436 Sentence denotes However, at a higher concentration (100 µM), inhibition of viral entry via SARS‐CoV‐1 S protein‐mediated cell fusion never exceeded 65% (inhibition efficiency), indicating that 35% of entry events take place via the endosomal cathepsin pathway.
T288 20437-20599 Sentence denotes Interestingly, treatment with a combination of EST (a cathepsin inhibitor) and 18 resulted in remarkably blocked infection (>95%) activity of pseudotyped viruses.
T289 20600-20603 Sentence denotes 109
T290 20604-20643 Sentence denotes Figure 8 Inhibitors targeting TMPRSS2.
T291 20644-20760 Sentence denotes TMPRSS, transmembrane serine protease A similar approach has been investigated to prevent viral entry of SARS‐CoV‐2.
T292 20761-20895 Sentence denotes Pöhlmann et al. reported the attainment of full inhibition efficiency with a combination of both 18 and E‐64d (a cathepsin inhibitor).
T293 20896-21039 Sentence denotes Both studies indicate that SARS‐CoV‐1 and 2 enter cells in a similar manner showing the potential of 18 as a candidate for further development.
T294 21040-21042 Sentence denotes 15
T295 21043-21209 Sentence denotes Recently, K11777 (19; Figure 8), a cysteine protease inhibitor, was shown in tissue cultures to inhibit SARS‐CoV‐1 and MERS‐CoV replication in the subnanomolar range.
T296 21210-21365 Sentence denotes 110 , 111 Future tissue culture and animal model studies should be conducted to clarify, whether its antiviral activity is mediated by targeting TMPRSS2.
T297 21366-21537 Sentence denotes Teicoplanin is a glycopeptide antibiotic used to prevent infections with Gram‐positive bacteria like methicillin‐resistant Staphylococcus aureus and Enterococcus faecalis.
T298 21538-21666 Sentence denotes It was found that teicoplanin inhibits the entry of SARS‐CoV‐1, MERS‐CoV, and Ebola virus by specifically targeting cathepsin L.
T299 21667-21787 Sentence denotes 112 This knowledge has also been used to block the entry of new SARS‐CoV‐2 pseudoviruses with an IC50 value of 1.66 µM.
T300 21788-21883 Sentence denotes Therefore, teicoplanin could be considered a potential candidate for the treatment of COVID‐19.
T301 21884-21887 Sentence denotes 113
T302 21889-21935 Sentence denotes 2.4 Small‐molecules as cathepsin L inhibitors
T303 21936-22111 Sentence denotes Human cathepsin L is a cysteine endopeptidase and plays a key role for infection efficiency by activation of the S protein into a fusogenic state to escape the late endosomes.
T304 22112-22263 Sentence denotes Targeting this protease with small molecules could interfere with virus‐cell entry and therefore be a possible intervention strategy for CoV infection.
T305 22264-22478 Sentence denotes 114 Bates et al. identified MDL28170 (20; Figure 9) as an antiviral compound that specifically inhibited cathepsin‐L‐mediated substrate cleavage, with an IC50 value of 2.5 nM and EC50 value in the range of 100 nM.
T306 22479-22579 Sentence denotes However, despite its potent inhibitory activity, no cytotoxicity data for 20 is currently available.
T307 22580-22583 Sentence denotes 115
T308 22584-22787 Sentence denotes Figure 9 Cathepsin L inhibitors with antiviral activity Diamond et al. reported CID 16725315 (21) and CID 23631927 (22; Figure 9) as viral entry inhibitors of SARS‐CoV in a cathepsin L inhibition assay.
T309 22788-22908 Sentence denotes Compound 21 could block cathepsin L with an IC50 value of 6.9 nM, while 22 showed slightly weaker potency (IC50, 56 nM).
T310 22909-23021 Sentence denotes Compound 22 was also found to inhibit Ebola virus infection (EC50, 193 nM) of human embryonic kidney 293T cells.
T311 23022-23117 Sentence denotes This compound did not show any sign of toxicity to human aortic endothelial cells up to 100 µM.
T312 23118-23210 Sentence denotes This data offers a new promising point for the treatment of SARS and Ebola virus infections.
T313 23211-23214 Sentence denotes 116
T314 23215-23396 Sentence denotes Screening of ~14 000 compounds in a cell‐based assay resulted in the identification of SSAA09E1 (23; Figure 9) as inhibitor of cathepsin L proteinase, with an IC50 value of 5.33 µM.
T315 23397-23526 Sentence denotes In a pseudotype‐based assay in 293T cells, the EC50 value of 23 was around 6.4 µM, and no cytotoxicity was detected below 100 µM.
T316 23527-23529 Sentence denotes 48
T317 23530-23622 Sentence denotes Phenotypic screening approaches led to the identification of several viral entry inhibitors.
T318 23623-23750 Sentence denotes This approach has the advantage of finding cellular‐active compounds, providing information on drug solubility and cell uptake.
T319 23751-23855 Sentence denotes 117 On the other hand, it is limited in terms of capacity compared to in silico target‐based screening.
T320 23856-24147 Sentence denotes Hsiang et al. identified emodin (24; Figure 9), the active component from Polygonum multiflorum and Rheum officinale, could block the interaction of S protein with ACE2, with an IC50 value of 10 µM and an EC50 value of 200 µM in an S protein‐pseudotyped retrovirus assay using Vero E6 cells.
T321 24148-24227 Sentence denotes However, the mechanism of action of this compound still needs to be determined.
T322 24228-24250 Sentence denotes 118 Sarafianos et al.
T323 24251-24502 Sentence denotes 48 found that SSAA09E3 (25), a benzamide derivative of 24, could prevent virus‐cell membrane fusion in pseudotype‐based and antiviral‐based assays, with an EC50 value of 9.7 µM, but a CC50 value of 20 µM indicates additional unknown cellular targets.
T324 24503-24665 Sentence denotes VE607 (26) was identified among 50 240 structurally diverse small molecules to specifically inhibit SARS‐CoV‐1 entry into cells using a phenotype‐based screening.
T325 24666-24772 Sentence denotes Its EC50 value was reported at 3.0 µM and it inhibited SARS‐CoV‐1 plaque formation with an EC50 of 1.6 µM.
T326 24773-24860 Sentence denotes 119 Cathepsin inhibitor E‐64‐D (27) blocked MERS‐CoV and SARS‐CoV‐1 infection as well.
T327 24861-24871 Sentence denotes 120 , 121