Here we report a single-center retrospective analysis on brain CT findings in 23 patients with COVID-19 infection (21 M, 2F, mean age 60.2 ± 7.9 years), admitted to the two mobile ICUs at our hospital. All patients received invasive mechanical ventilation, six of them had veno-venous extracorporeal membrane oxygenation (VV-ECMO). As soon as clinical state allowed, both chest and brain CT in one run were performed.