There are multiple factors which influence frequency of epileptic seizures, including systemic and environmental factors.1 COVID-19 therefore may exacerbate epileptic seizures from associated systemic effects not directly related to SARS-CoV-2 virus central nervous system (CNS) infection. Reports of seizures in COVID-19 patients should be interpreted in this context. As detailed below, cohort studies of patients with COVID-19 show that neurological complications are relatively uncommon and occur with increased frequency in patients with more severe systemic illness.2,3 Lack of early neurological signs and symptoms suggest absence of early direct CNS infection by the SARS-CoV-2 virus. Later neurological manifestations of COVID-19 could be related to either systemic complications of severe infection or direct CNS infection by SARS-CoV-2 virus, which remains uncertain from available data.