as small. Gautret et al.[57] Open label, nonrandom cohort study HCQ group: n = 12; HCQ+azithromycin group: n = 6; control group: n = 12 HCQ (200 mg/3 times/day for 10 days) HCQ alone or in combination with azithromycin could effectively eliminate nasopharyngeal virus in 3–5 days. Nasopharyngeal virus determination was used as main endpoint. Small sample size; Six patients dropped out due to critical illness or intolerance to the drug; Lack of clinical outcomes; Limited follow-up results. Gautret et al