PMC:7441788 / 13819-14033 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T97","span":{"begin":16,"end":25},"obj":"Body_part"},{"id":"T98","span":{"begin":26,"end":29},"obj":"Body_part"},{"id":"T99","span":{"begin":131,"end":133},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma66595"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T163","span":{"begin":48,"end":65},"obj":"http://purl.obolibrary.org/obo/PR_000024990"},{"id":"T164","span":{"begin":131,"end":133},"obj":"http://purl.obolibrary.org/obo/CLO_0001562"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T182","span":{"begin":26,"end":29},"obj":"Chemical"},{"id":"T183","span":{"begin":55,"end":65},"obj":"Chemical"},{"id":"T184","span":{"begin":93,"end":95},"obj":"Chemical"},{"id":"T185","span":{"begin":162,"end":178},"obj":"Chemical"},{"id":"T186","span":{"begin":174,"end":178},"obj":"Chemical"}],"attributes":[{"id":"A182","pred":"chebi_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A183","pred":"chebi_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A184","pred":"chebi_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A185","pred":"chebi_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A186","pred":"chebi_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T114","span":{"begin":26,"end":29},"obj":"Chemical"},{"id":"T115","span":{"begin":93,"end":95},"obj":"Chemical"},{"id":"T116","span":{"begin":162,"end":178},"obj":"Chemical"}],"attributes":[{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"530","span":{"begin":117,"end":133},"obj":"Gene"},{"id":"540","span":{"begin":93,"end":99},"obj":"Chemical"},{"id":"541","span":{"begin":162,"end":178},"obj":"Chemical"}],"attributes":[{"id":"A530","pred":"pubann:denotes","subj":"530","obj":"Gene:5319"},{"id":"A541","pred":"pubann:denotes","subj":"541","obj":"MESH:D016718"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1064","span":{"begin":55,"end":65},"obj":"Protein"},{"id":"T1066","span":{"begin":117,"end":133},"obj":"Protein"}],"attributes":[{"id":"A1064","pred":"uniprot_id","subj":"T1064","obj":"https://www.uniprot.org/uniprot/P51527"},{"id":"A1065","pred":"uniprot_id","subj":"T1064","obj":"https://www.uniprot.org/uniprot/P51526"},{"id":"A1066","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/Q05017"},{"id":"A1067","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P86780"},{"id":"A1068","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P86517"},{"id":"A1069","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P86043"},{"id":"A1070","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P82971"},{"id":"A1071","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P59066"},{"id":"A1072","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P50393"},{"id":"A1073","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P50392"},{"id":"A1074","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P49147"},{"id":"A1075","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P47713"},{"id":"A1076","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P47712"},{"id":"A1077","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P43434"},{"id":"A1078","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P18999"},{"id":"A1079","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P14419"},{"id":"A1080","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P0DPT8"},{"id":"A1081","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P0DP54"},{"id":"A1082","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P0CV89"},{"id":"A1083","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P0C8L9"},{"id":"A1084","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P06596"},{"id":"A1085","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P04362"},{"id":"A1086","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P04055"},{"id":"A1087","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P04054"},{"id":"A1088","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P00630"},{"id":"A1089","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P00594"},{"id":"A1090","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/P00593"},{"id":"A1091","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/O77793"},{"id":"A1092","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/O70320"},{"id":"A1093","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/O54728"},{"id":"A1094","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/F5CPF0"},{"id":"A1095","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/C0HLL2"},{"id":"A1096","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/C0HLB8"},{"id":"A1097","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/B3EWQ8"},{"id":"A1098","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/B3EWP6"},{"id":"A1099","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/B2R4H5"},{"id":"A1100","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/B1WAZ6"},{"id":"A1101","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/B1AKG4"},{"id":"A1102","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A8KAX2"},{"id":"A1103","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A6H6K5"},{"id":"A1104","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A5JGM7"},{"id":"A1105","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A4IFJ5"},{"id":"A1106","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A0A5C2A2T2"},{"id":"A1107","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A0A5C1ZXT8"},{"id":"A1108","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/A0A5C1ZW08"},{"id":"A1109","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/Q9Z0Y2"},{"id":"A1110","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/Q9TWL9"},{"id":"A1111","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/Q9TT38"},{"id":"A1112","pred":"uniprot_id","subj":"T1066","obj":"https://www.uniprot.org/uniprot/Q9PRZ0"},{"id":"A1113","pred":"uniprot_id","subj":"T106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by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T110","span":{"begin":66,"end":76},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T111","span":{"begin":197,"end":207},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T97","span":{"begin":16,"end":25},"obj":"Body_part"},{"id":"T98","span":{"begin":26,"end":29},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma66836"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma74412"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T59","span":{"begin":48,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T60","span":{"begin":55,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T61","span":{"begin":117,"end":130},"obj":"http://purl.obolibrary.org/obo/GO_0004623"},{"id":"T62","span":{"begin":148,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0008152"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T56","span":{"begin":48,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T57","span":{"begin":55,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T58","span":{"begin":148,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0008152"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T56","span":{"begin":48,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0032606"},{"id":"T57","span":{"begin":55,"end":76},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T58","span":{"begin":148,"end":158},"obj":"http://purl.obolibrary.org/obo/GO_0008152"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"LitCovid-PubTator","denotations":[{"id":"530","span":{"begin":117,"end":133},"obj":"Gene"},{"id":"540","span":{"begin":93,"end":99},"obj":"Chemical"},{"id":"541","span":{"begin":162,"end":178},"obj":"Chemical"}],"attributes":[{"id":"A530","pred":"tao:has_database_id","subj":"530","obj":"Gene:5319"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"MESH:D016718"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}

{"project":"2_test","denotations":[{"id":"32496926-25821216-132195697","span":{"begin":78,"end":80},"obj":"25821216"}],"text":"y by inhibiting cytosolic DNA, thereby reducing type I interferon production [44]. In vitro, CQ/HCQ can also inhibit phospholipase A2, altering the metabolism of arachidonic acid, and reducing the production of pro"}