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PMC:7441788 / 134-1685 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 248-257 Body_part denotes malarials http://purl.org/sig/ont/fma/fma46831
T2 430-438 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T3 9-33 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T4 35-43 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 56-103 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 56-89 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T7 105-113 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 196-204 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 344-352 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 609-617 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 722-730 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 893-901 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1146-1154 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1241-1249 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 1356-1364 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T16 1439-1447 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 476-484 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T2 522-530 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 585-586 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 619-620 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T5 842-843 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 1082-1083 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T5 216-221 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T6 259-270 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T7 272-274 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T8 280-298 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T9 354-356 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T10 679-681 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T11 806-808 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T12 844-853 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T13 1045-1047 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T14 1084-1093 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T15 1218-1220 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T16 1332-1334 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T17 1414-1425 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T18 1429-1431 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T1 228-241 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigation http://purl.bioontology.org/ontology/MEDDRA/10062026

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T3 259-270 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T4 272-274 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T5 280-298 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T6 354-356 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T7 679-681 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T8 806-808 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T9 844-853 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T10 1045-1047 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T11 1084-1093 Chemical denotes macrolide http://purl.obolibrary.org/obo/CHEBI_25106
T12 1218-1220 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T13 1332-1334 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638
T14 1429-1431 Chemical denotes CQ http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T2 9-33 Species denotes Coronavirus Disease 2019 NCBItxid:2697049
T3 35-43 Species denotes COVID-19 NCBItxid:2697049
T4 56-103 Species denotes severe acute respiratory syndrome coronavirus 2 NCBItxid:2697049
T5 105-115 Species denotes SARS-CoV-2 NCBItxid:2697049
T6 196-204 Species denotes COVID-19 NCBItxid:2697049
T7 344-352 Species denotes COVID-19 NCBItxid:2697049
T8 609-617 Species denotes COVID-19 NCBItxid:2697049
T9 722-732 Species denotes SARS-CoV-2 NCBItxid:2697049
T10 893-901 Species denotes COVID-19 NCBItxid:2697049
T11 1146-1154 Species denotes COVID-19 NCBItxid:2697049
T12 1241-1249 Species denotes COVID-19 NCBItxid:2697049
T13 1356-1364 Species denotes COVID-19 NCBItxid:2697049
T14 1439-1447 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes ABSTRACT
T7 9-141 Sentence denotes Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide.
T8 142-205 Sentence denotes Antiviral therapy is the most important treatment for COVID-19.
T9 206-353 Sentence denotes Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19.
T10 354-531 Sentence denotes CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity.
T11 532-618 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T12 619-768 Sentence denotes A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist.
T13 769-994 Sentence denotes Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects.
T14 995-1155 Sentence denotes However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19.
T15 1156-1259 Sentence denotes Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients.
T16 1260-1551 Sentence denotes Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
40 806-812 Gene denotes CQ/HCQ
41 56-103 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
42 105-115 Species denotes SARS-CoV-2 Tax:2697049
43 407-420 Species denotes coronaviruses Tax:11118
44 697-710 Species denotes coronaviruses Tax:11118
45 722-732 Species denotes SARS-CoV-2 Tax:2697049
46 1132-1140 Species denotes patients Tax:9606
47 1250-1258 Species denotes patients Tax:9606
48 259-270 Chemical denotes chloroquine MESH:D002738
49 272-274 Chemical denotes CQ MESH:D002738
50 280-298 Chemical denotes hydroxychloroquine MESH:D006886
51 300-303 Chemical denotes HCQ MESH:D006886
52 679-681 Chemical denotes CQ MESH:D002738
53 682-685 Chemical denotes HCQ MESH:D006886
54 844-853 Chemical denotes macrolide MESH:D018942
55 1045-1051 Chemical denotes CQ/HCQ
56 1084-1093 Chemical denotes macrolide MESH:D018942
57 1218-1220 Chemical denotes CQ MESH:D002738
58 1221-1224 Chemical denotes HCQ MESH:D006886
59 1332-1334 Chemical denotes CQ MESH:D002738
60 1335-1338 Chemical denotes HCQ MESH:D006886
61 1429-1431 Chemical denotes CQ MESH:D002738
62 1432-1435 Chemical denotes HCQ MESH:D006886
63 9-33 Disease denotes Coronavirus Disease 2019 MESH:C000657245
64 35-43 Disease denotes COVID-19 MESH:C000657245
65 196-204 Disease denotes COVID-19 MESH:C000657245
66 344-352 Disease denotes COVID-19 MESH:C000657245
67 609-617 Disease denotes COVID-19 MESH:C000657245
68 893-901 Disease denotes COVID-19 MESH:C000657245
69 933-946 Disease denotes delay disease MESH:D003141
70 1146-1154 Disease denotes COVID-19 MESH:C000657245
71 1241-1249 Disease denotes COVID-19 MESH:C000657245
72 1356-1364 Disease denotes COVID-19 MESH:C000657245
73 1439-1447 Disease denotes COVID-19 MESH:C000657245

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T1 21-28 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T2 142-151 http://purl.obolibrary.org/obo/IDO_0000559 denotes Antiviral
T3 881-889 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T4 939-946 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T1 248-257 Body_part denotes malarials http://purl.org/sig/ont/fma/fma46831
T2 430-438 Body_part denotes endosome http://purl.org/sig/ont/fma/fma67180

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T1 439-452 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T2 476-491 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 9-33 Disease denotes Coronavirus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T3 35-43 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 56-103 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 105-115 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T6 196-204 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 344-352 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 609-617 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 722-732 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T10 893-901 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1146-1154 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1241-1249 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1356-1364 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1439-1447 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1183-1204 Phenotype denotes prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T1 439-452 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T2 476-491 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 439-452 http://purl.obolibrary.org/obo/GO_0045851 denotes acidification
T2 476-491 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
40 806-812 Gene denotes CQ/HCQ
41 56-103 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
42 105-115 Species denotes SARS-CoV-2 Tax:2697049
43 407-420 Species denotes coronaviruses Tax:11118
44 697-710 Species denotes coronaviruses Tax:11118
45 722-732 Species denotes SARS-CoV-2 Tax:2697049
46 1132-1140 Species denotes patients Tax:9606
47 1250-1258 Species denotes patients Tax:9606
48 259-270 Chemical denotes chloroquine MESH:D002738
49 272-274 Chemical denotes CQ MESH:D002738
50 280-298 Chemical denotes hydroxychloroquine MESH:D006886
51 300-303 Chemical denotes HCQ MESH:D006886
52 679-681 Chemical denotes CQ MESH:D002738
53 682-685 Chemical denotes HCQ MESH:D006886
54 844-853 Chemical denotes macrolide MESH:D018942
55 1045-1051 Chemical denotes CQ/HCQ
56 1084-1093 Chemical denotes macrolide MESH:D018942
57 1218-1220 Chemical denotes CQ MESH:D002738
58 1221-1224 Chemical denotes HCQ MESH:D006886
59 1332-1334 Chemical denotes CQ MESH:D002738
60 1335-1338 Chemical denotes HCQ MESH:D006886
61 1429-1431 Chemical denotes CQ MESH:D002738
62 1432-1435 Chemical denotes HCQ MESH:D006886
63 9-33 Disease denotes Coronavirus Disease 2019 MESH:C000657245
64 35-43 Disease denotes COVID-19 MESH:C000657245
65 196-204 Disease denotes COVID-19 MESH:C000657245
66 344-352 Disease denotes COVID-19 MESH:C000657245
67 609-617 Disease denotes COVID-19 MESH:C000657245
68 893-901 Disease denotes COVID-19 MESH:C000657245
69 933-946 Disease denotes delay disease MESH:D003141
70 1146-1154 Disease denotes COVID-19 MESH:C000657245
71 1241-1249 Disease denotes COVID-19 MESH:C000657245
72 1356-1364 Disease denotes COVID-19 MESH:C000657245
73 1439-1447 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes ABSTRACT
T7 9-141 Sentence denotes Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide.
T8 142-205 Sentence denotes Antiviral therapy is the most important treatment for COVID-19.
T9 206-353 Sentence denotes Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19.
T10 354-531 Sentence denotes CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity.
T11 532-618 Sentence denotes These multiple mechanisms may work together to exert a therapeutic effect on COVID-19.
T12 619-768 Sentence denotes A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist.
T13 769-994 Sentence denotes Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects.
T14 995-1155 Sentence denotes However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19.
T15 1156-1259 Sentence denotes Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients.
T16 1260-1551 Sentence denotes Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1183-1204 Phenotype denotes prolonged QT interval http://purl.obolibrary.org/obo/HP_0001657