Cytochromes P450 (CYP) isozymes play crucial roles in drug metabolism. It has been observed that TF2a, TF3, and remdesivir are a substrate of CYP3A4 and hence, can be efficiently metabolized by CYP3A4. On the other hand, EGCG is a CYP3A4 inhibitor (Table S5 in the Supplementary Information). On a separate note, EGCG is predominantly metabolized in the small intestine and liver by the conjugate formation of glucuronide, methyl sulfates in the urine and plasma (Chow et al. 2005).