olvation energy; ΔGnp, non-polar solvation energy, and ΔGbind, estimated binding affinity. Table 4. Energetic components of the binding free energy of RdRp and natural polyphenols along with remdesivir complexes in kcal/mol. Data are represented as average ± SEM. Components Remdesivir EGCG TF3 TF2b TF2a ΔEvdW