It might seem obvious that a layer-by-layer nanocoating strategy will work. However, literature and patent literature surveys have not revealed a significant effort toward antiviral nanocoatings. From the abundant bactericidal reports, it can be deduced that the LbL technique will produce antiviral surfaces. However, we foresee success because surface recognition mechanisms between organisms, hosts, and guests, rely on similar principles and that is protein-polysaccharide interactions.