The stemness phenotype within a tumor can also be mediated via SASP (526). Several studies address the strong pro-tumorigenic phenotype (526) whose cytokines can mediate the maintenance of CSCs. The most prominent interleukins (IL) of SASP are IL-1,−6, and−8 (526). These cytokines can influence the CSC phenotype and functionality and therefore influence the plasticity phenotype of CSCs.