DATA AVAILABILITY
The single-cell sequencing data is deposited in the Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics (BIG, https://bigd.big.ac.cn/gsa-human/), Chinese Academy of Sciences, with Project Accession No. PRJCA002865 and GSA Accession No. HSA000203. In cohort-3 scRNA seq, YCR and ACR data were obtained from the Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics (BIG, http://gsa.big.ac.cn), Chinese Academy of Sciences, with Project Accession No. PRJCA002413 and GSA Accession No. CRA002497.