chromVAR
We measured global TF activity using chromVAR15. We used the cell-by-peaks and the Catalog of Inferred Sequence Binding Preferences (CIS-BP) motif (from chromVAR motifs “human_pwms_v1”) matches within these peaks from motifmatchr. We then computed the GC-bias-corrected deviation scores using the chromVAR “deviationScores” function.