Notably, CLEC12A and TXNIP, which are critical for the antigen-presentation function of DCs; and MALAT1 and AHR, which are critical to inducing tolerogenic DCs (Son et al., 2008; Hutten et al., 2016; Wu et al., 2018), were decreased in AA DCs (Figs. 3I, S7G, and S7I), reflecting the decreased antigen-presenting ability of aged DCs (Fig. S7H).