The recent COVID-19 emergency affected worldwide healthcare systems causing a rapid redefinition of the daily medical practice organization at every level [1–3]. To contain the spread of COVID-19 and to optimize hospital resources, all non-urgent diagnostic imaging studies, including nuclear cardiology procedures, have been postponed limiting the use of all available elective diagnostic imaging tools [4]. Suddenly, all the gained knowledge regarding the prognostic power of early diagnosis in all medicine fields have given the way to emergency measures with great concern about the clinical implications of primary prevention tool stoppage [5]. The reduction of timely diagnosis may have substantial consequences on diseases with high mortality rate, such as coronary artery disease (CAD) [6]. However, the real effect of this abrupt interruption has not yet been quantified.