The results of this study show that, due to the restrictive medical measures for COVID-19 emergency, the number of stress SPECT-MPI procedures was significantly reduced during the pandemic compared with the corresponding months of the previous 3 years (i.e., 2017, 2018, and 2019). However, the proportion of abnormal stress SPECT-MPI was not different between the two study periods. This finding suggests that a significant number of patients, who would have performed MPI test with abnormal results, have been missed during the COVID-19 pandemic. Given the mean number of 139 abnormal stress SPECT-MPI detected at our institution in the previous 3 years during the time range corresponding to the COVID-19 pandemic, and given the 44 abnormal tests observed during COVID-19 outbreak, it can be hypothesized that there is a 68% of abnormal test missed.