Neurosurgical scientific societies identified the transnasal skull base surgery, transoral and transfacial corridors, as the most riskful for diffusion of COVID-19 and also recommended to spare the opening of paranasal cavities and mastoids during transcranial corridors [7, 19–21, 23]. To our knowledge, “maximally safe” protocols for performing neurosurgical procedures, while minimizing the risks of COVID-19 diffusion, include the use of adequate PPE, OR settings, and the advice of reducing aerosol/droplets generating maneuvers [15, 19, 21].