The FDA-approved tapeworm medication, niclosamide, reported as having antiviral activity against SARS-CoV and MERS-CoV is presently under investigation as a SARS-CoV-2 agent (169). Niclosamide has been reported (unpublished results; preprint) to be one of 24 FDA-approved drugs to show in vitro activity against SARS-CoV-2, with an IC50 of 0.28 μM (https://www.biorxiv.org/content/10.1101/2020.03.20.999730v3.full.pdf). The inhibitory activity of niclosamide against SKP2, which diminishes MERS-CoV replication and augments autophagy (170), is proposed to be the potential mechanism through which niclosamide acts against SARS-CoV-2. Niclosamide was demonstrated to synergize in preclinical studies with imatinib and other kinase inhibitors against different malignancies. For instance, synergy between niclosamide and imatinib, as well as niclosamide and dasatinib or ponatinib, against CML cells was demonstrated (171). Niclosamide was also found to potentiate the effects of erlotinib against head and neck cancer cells through STAT3 inhibition (172), with erlotinib against human colon cancer lines (173), and with sorafenib against human renal cell cancer cells (174).