Kinase inhibitors with good safety profiles and desirable pharmacokinetics properties, including minimal association with drug transporters and CYP enzymes, warrant testing in combination with antiviral agents or other targeted agents, to more effectively decrease viral load and potentially more dramatically improve COVID-19 symptoms. There are currently numerous direct antiviral agents that are under consideration for COVID-19 (several prominent investigational drugs are shown in Fig. 4).
Figure 4. Drug therapies under investigation for COVID-19.