Abemaciclib (Verzenio and Verzenios)
(Eli Lilly) Following oral dose 200 mg,Cmax=158 ng/mL (after 6 h);
Tmax=4-6 h following oral dose 50-275 mg, but could range up to 24 h;
Absolute bioavailability=45%;
Vd=690.3L Metabolized by CYP3A4 200 mg tablet orally twice daily (as single agent);
95-98% (HAS, AAG) There is a small risk of potentially severe lung inflammation in abemaciclib-treated patients.