Food increases exposure; following 15 daily doses of bosutinib 500 mg with food: Cmax = 200 ng/mL; AUC = 3650 ng∙h/mL;
compared to initial administration, plasma drug exposure did not increase significantly; following 15 daily doses 400 mg once daily:
AUC =2235 ng*h/mL;
Tmax=4 h;
Has acceptable exposure;
Vd= 6080 ± 1230 L;
(substrate of ABCB1)