Tofacitinib (XELJANZ XR) (ulcerative colitis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis; JAK1, JAK3) JAK1, JAK2, JAK3, TYK2 No AAK1 inhibitory activity (47) Anti-inflammatory and cytokine suppression (109) (110) (107) (111)