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PMC:7408073 / 98067-98738 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T512 379-384 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T513 528-536 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3437 272-276 Gene denotes ACE2 Gene:59272
3438 418-422 Gene denotes ACE2 Gene:59272
3439 508-512 Gene denotes ACE2 Gene:59272
3440 590-594 Gene denotes ACE2 Gene:59272
3441 615-619 Gene denotes ACE2 Gene:59272
3442 522-527 Gene denotes spike Gene:43740568
3443 397-405 Species denotes patients Tax:9606
3444 412-417 Species denotes human Tax:9606
3445 631-641 Species denotes SARS-CoV-2 Tax:2697049
3446 345-356 Disease denotes hypercapnia MESH:D006935
3447 388-396 Disease denotes COVID-19 MESH:C000657245
3504 147-151 Gene denotes ACE2 Gene:59272
3505 128-131 Gene denotes MLN Gene:4295
3506 54-62 Species denotes patients Tax:9606
3507 45-53 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T548 45-53 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T549 388-396 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T550 631-639 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T551 631-635 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1199 177-180 http://purl.obolibrary.org/obo/CLO_0002096 denotes C16
T1200 241-244 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T1201 287-295 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1202 379-384 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lungs
T1203 412-417 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T1204 423-431 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1205 595-603 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T1206 658-660 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T445 119-127 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T21827 147-161 Chemical denotes ACE2 inhibitor http://purl.obolibrary.org/obo/CHEBI_147289
T447 152-161 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T82941 177-180 Chemical denotes C16 http://purl.obolibrary.org/obo/CHEBI_15756
T449 528-536 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T477 0-671 Sentence denotes Briefly, one of the best candidates to treat COVID-19 patients, but not to prevent viral entry, is the small synthetic molecule MLN-4760 (specific ACE2 inhibitor, also known as C16, GL1001 or ORE1001, [113]) for the following reasons:(1) It has been shown to bind/inhibit ACE2 enzymatic activity even at low/acidic pH (pH 6.5, [115]) typical of hypercapnia (as it might occur in lungs of COVID-19 patients) when human ACE2 activity is maximal [79]; nevertheless, it retains its inhibitory effects on soluble ACE2 bound to spike proteins [24], indicating that it is able to bind and inhibit ACE2 activity regardless ACE2 binding to SARS-CoV-2 particles or to S1 fragments.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T161 345-356 Phenotype denotes hypercapnia http://purl.obolibrary.org/obo/HP_0012416

2_test

Id Subject Object Predicate Lexical cue
32708755-12358520-20679021 202-205 12358520 denotes 113
32708755-22777933-20679022 328-331 22777933 denotes 115
32708755-15791205-20679023 538-540 15791205 denotes 24