PMC:7408073 / 86880-87283 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T487","span":{"begin":123,"end":129},"obj":"Body_part"},{"id":"T488","span":{"begin":201,"end":207},"obj":"Body_part"}],"attributes":[{"id":"A487","pred":"fma_id","subj":"T487","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A488","pred":"fma_id","subj":"T488","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"3005","span":{"begin":65,"end":70},"obj":"Gene"},{"id":"3006","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"3007","span":{"begin":347,"end":355},"obj":"Gene"},{"id":"3008","span":{"begin":358,"end":366},"obj":"Gene"},{"id":"3009","span":{"begin":373,"end":376},"obj":"Gene"},{"id":"3013","span":{"begin":243,"end":249},"obj":"Gene"},{"id":"3014","span":{"begin":387,"end":395},"obj":"Gene"},{"id":"3015","span":{"begin":59,"end":64},"obj":"Species"}],"attributes":[{"id":"A3005","pred":"tao:has_database_id","subj":"3005","obj":"Gene:302668"},{"id":"A3006","pred":"tao:has_database_id","subj":"3006","obj":"Gene:59272"},{"id":"A3007","pred":"tao:has_database_id","subj":"3007","obj":"Gene:284"},{"id":"A3008","pred":"tao:has_database_id","subj":"3008","obj":"Gene:284"},{"id":"A3009","pred":"tao:has_database_id","subj":"3009","obj":"Gene:59272"},{"id":"A3013","pred":"tao:has_database_id","subj":"3013","obj":"Gene:24179"},{"id":"A3014","pred":"tao:has_database_id","subj":"3014","obj":"Gene:284"},{"id":"A3015","pred":"tao:has_database_id","subj":"3015","obj":"Tax:9606"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1041","span":{"begin":13,"end":14},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1042","span":{"begin":59,"end":64},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T1043","span":{"begin":111,"end":119},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T1044","span":{"begin":123,"end":129},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T1045","span":{"begin":189,"end":197},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1046","span":{"begin":201,"end":207},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T1047","span":{"begin":221,"end":222},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1048","span":{"begin":265,"end":266},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1049","span":{"begin":299,"end":300},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T56689","span":{"begin":111,"end":119},"obj":"Chemical"},{"id":"T363","span":{"begin":247,"end":249},"obj":"Chemical"}],"attributes":[{"id":"A52193","pred":"chebi_id","subj":"T56689","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A23292","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T424","span":{"begin":0,"end":403},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115]."}

{"project":"2_test","denotations":[{"id":"32708755-22777933-20678977","span":{"begin":209,"end":212},"obj":"22777933"},{"id":"32708755-22777933-20678978","span":{"begin":398,"end":401},"obj":"22777933"}],"text":"Of interest, a report that described the ex vivo effect of human rACE2 on the levels of several endogenous Ang peptides in plasma samples, thus mimicking an acute increase of systemic ACE2 activity in plasma [115] showed a strong reduction of Ang II (as expected), a moderate reduction of Ang I and a significant (more than five-fold) increase of Ang (1–9), Ang (1–7) and (ACE-produced) Ang (1–5) [115]."}