llular ADAM17/TACE metalloprotease, which concomitantly induces shedding/production of TNFα [17,18]. Interestingly, ACE2 shedding is enhanced not only by binding with spike protein [17,18], but also by IL-1β and TNFα inflammatory cytokines [16], cytokines that are secreted at relatively high concentration in COVID-19 patients [2]. Moreover, soluble (s)ACE2 (induced or not by virus binding) released from huma