PMC:7408073 / 30291-30662 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T61","span":{"begin":99,"end":123},"obj":"Body_part"}],"attributes":[{"id":"A61","pred":"uberon_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1097","span":{"begin":136,"end":141},"obj":"Gene"},{"id":"1098","span":{"begin":143,"end":146},"obj":"Gene"},{"id":"1099","span":{"begin":151,"end":155},"obj":"Gene"},{"id":"1100","span":{"begin":226,"end":234},"obj":"Gene"},{"id":"1101","span":{"begin":237,"end":245},"obj":"Gene"},{"id":"1102","span":{"begin":275,"end":285},"obj":"Gene"},{"id":"1103","span":{"begin":317,"end":321},"obj":"Gene"},{"id":"1104","span":{"begin":215,"end":223},"obj":"Gene"},{"id":"1105","span":{"begin":354,"end":364},"obj":"Species"},{"id":"1106","span":{"begin":99,"end":104},"obj":"Gene"},{"id":"1107","span":{"begin":207,"end":213},"obj":"Gene"},{"id":"1108","span":{"begin":4,"end":11},"obj":"Disease"},{"id":"1109","span":{"begin":39,"end":50},"obj":"Disease"}],"attributes":[{"id":"A1097","pred":"tao:has_database_id","subj":"1097","obj":"Gene:5972"},{"id":"A1098","pred":"tao:has_database_id","subj":"1098","obj":"Gene:59272"},{"id":"A1099","pred":"tao:has_database_id","subj":"1099","obj":"Gene:59272"},{"id":"A1100","pred":"tao:has_database_id","subj":"1100","obj":"Gene:284"},{"id":"A1101","pred":"tao:has_database_id","subj":"1101","obj":"Gene:284"},{"id":"A1102","pred":"tao:has_database_id","subj":"1102","obj":"Gene:3827"},{"id":"A1103","pred":"tao:has_database_id","subj":"1103","obj":"Gene:59272"},{"id":"A1104","pred":"tao:has_database_id","subj":"1104","obj":"Gene:284"},{"id":"A1105","pred":"tao:has_database_id","subj":"1105","obj":"Tax:2697049"},{"id":"A1106","pred":"tao:has_database_id","subj":"1106","obj":"Gene:5972"},{"id":"A1107","pred":"tao:has_database_id","subj":"1107","obj":"Gene:24179"},{"id":"A1108","pred":"tao:has_database_id","subj":"1108","obj":"MESH:D000860"},{"id":"A1109","pred":"tao:has_database_id","subj":"1109","obj":"MESH:D006935"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T206","span":{"begin":354,"end":362},"obj":"Disease"},{"id":"T207","span":{"begin":354,"end":358},"obj":"Disease"}],"attributes":[{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T371","span":{"begin":70,"end":78},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T372","span":{"begin":87,"end":91},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T373","span":{"begin":302,"end":310},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T258","span":{"begin":105,"end":116},"obj":"Chemical"},{"id":"T259","span":{"begin":200,"end":203},"obj":"Chemical"},{"id":"T260","span":{"begin":207,"end":210},"obj":"Chemical"},{"id":"T261","span":{"begin":211,"end":213},"obj":"Chemical"},{"id":"T262","span":{"begin":215,"end":218},"obj":"Chemical"},{"id":"T263","span":{"begin":226,"end":229},"obj":"Chemical"},{"id":"T264","span":{"begin":237,"end":240},"obj":"Chemical"},{"id":"T265","span":{"begin":264,"end":274},"obj":"Chemical"},{"id":"T266","span":{"begin":275,"end":285},"obj":"Chemical"}],"attributes":[{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T55","span":{"begin":156,"end":165},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-sentences","denotations":[{"id":"T143","span":{"begin":0,"end":371},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T53","span":{"begin":4,"end":11},"obj":"Phenotype"},{"id":"T54","span":{"begin":39,"end":50},"obj":"Phenotype"}],"attributes":[{"id":"A53","pred":"hp_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/HP_0012418"},{"id":"A54","pred":"hp_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/HP_0012416"}],"text":"(2) Hypoxia in combination or not with hypercapnia can upregulate the activity of both arms of the renin–angiotensin system by inducing renin, ACE and ACE2 synthesis, which can increase expression of Ang I, Ang II, Ang (1–7), Ang (1–9), Ang (1–5) and the inactive metabolite bradykinin (1–7), but also membrane bound ACE2, finally giving more chances to SARS-CoV-2 entry."}