PMC:7408073 / 22615-23134 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T156","span":{"begin":47,"end":51},"obj":"Body_part"},{"id":"T157","span":{"begin":189,"end":193},"obj":"Body_part"},{"id":"T158","span":{"begin":194,"end":201},"obj":"Body_part"},{"id":"T159","span":{"begin":397,"end":401},"obj":"Body_part"}],"attributes":[{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T51","span":{"begin":47,"end":51},"obj":"Body_part"},{"id":"T52","span":{"begin":189,"end":193},"obj":"Body_part"},{"id":"T53","span":{"begin":397,"end":401},"obj":"Body_part"}],"attributes":[{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"LitCovid-PubTator","denotations":[{"id":"806","span":{"begin":239,"end":243},"obj":"Gene"},{"id":"807","span":{"begin":256,"end":264},"obj":"Gene"},{"id":"808","span":{"begin":300,"end":304},"obj":"Gene"},{"id":"809","span":{"begin":347,"end":351},"obj":"Gene"},{"id":"810","span":{"begin":380,"end":384},"obj":"Gene"},{"id":"811","span":{"begin":432,"end":436},"obj":"Gene"},{"id":"812","span":{"begin":496,"end":504},"obj":"Gene"},{"id":"879","span":{"begin":271,"end":277},"obj":"Gene"},{"id":"880","span":{"begin":245,"end":251},"obj":"Gene"},{"id":"947","span":{"begin":83,"end":99},"obj":"Disease"}],"attributes":[{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Gene:70008"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"Gene:11727"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"Gene:70008"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"Gene:70008"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"Gene:70008"},{"id":"A811","pred":"tao:has_database_id","subj":"811","obj":"Gene:70008"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"Gene:11727"},{"id":"A879","pred":"tao:has_database_id","subj":"879","obj":"Gene:24179"},{"id":"A880","pred":"tao:has_database_id","subj":"880","obj":"Gene:24179"},{"id":"A947","pred":"tao:has_database_id","subj":"947","obj":"MESH:D011654"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T287","span":{"begin":47,"end":51},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T288","span":{"begin":47,"end":51},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T289","span":{"begin":189,"end":193},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T290","span":{"begin":189,"end":193},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T291","span":{"begin":385,"end":393},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T292","span":{"begin":397,"end":401},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T293","span":{"begin":397,"end":401},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T294","span":{"begin":446,"end":454},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T163","span":{"begin":245,"end":248},"obj":"Chemical"},{"id":"T164","span":{"begin":249,"end":251},"obj":"Chemical"},{"id":"T165","span":{"begin":256,"end":259},"obj":"Chemical"},{"id":"T166","span":{"begin":271,"end":274},"obj":"Chemical"},{"id":"T167","span":{"begin":275,"end":277},"obj":"Chemical"},{"id":"T168","span":{"begin":496,"end":499},"obj":"Chemical"}],"attributes":[{"id":"A163","pred":"chebi_id","subj":"T163","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A164","pred":"chebi_id","subj":"T164","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A165","pred":"chebi_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A166","pred":"chebi_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A167","pred":"chebi_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A168","pred":"chebi_id","subj":"T168","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"LitCovid-sentences","denotations":[{"id":"T108","span":{"begin":109,"end":316},"obj":"Sentence"},{"id":"T109","span":{"begin":317,"end":506},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T47","span":{"begin":83,"end":99},"obj":"Phenotype"}],"attributes":[{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0100598"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}

{"project":"2_test","denotations":[{"id":"32708755-16007097-20678720","span":{"begin":101,"end":103},"obj":"16007097"},{"id":"32708755-16001071-20678721","span":{"begin":104,"end":106},"obj":"16001071"}],"text":" suggesting their involvement in the increased lung microvascular permeability and pulmonary oedema [14,15]. Indeed, this condition might subsequently favour the diffusion, in neighbouring lung tissues and systemic circulation, of both (s)ACE2, Ang II and Ang (1–7), the Ang II-derived product of (s)ACE2 processing. As already proposed, enhanced ACE2 shedding may locally reduce ACE2 activity in lung, however, it likely increases ACE2 systemic activity and subsequent production of circulating Ang (1–7). Interestingl"}