PMC:7408073 / 20814-21323 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T141","span":{"begin":395,"end":400},"obj":"Body_part"},{"id":"T142","span":{"begin":473,"end":479},"obj":"Body_part"}],"attributes":[{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma62970"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T45","span":{"begin":395,"end":400},"obj":"Body_part"}],"attributes":[{"id":"A45","pred":"uberon_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"LitCovid-PubTator","denotations":[{"id":"786","span":{"begin":16,"end":19},"obj":"Gene"},{"id":"787","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"788","span":{"begin":83,"end":91},"obj":"Gene"},{"id":"789","span":{"begin":113,"end":116},"obj":"Gene"},{"id":"790","span":{"begin":202,"end":210},"obj":"Gene"},{"id":"791","span":{"begin":212,"end":216},"obj":"Gene"},{"id":"792","span":{"begin":227,"end":235},"obj":"Gene"},{"id":"793","span":{"begin":310,"end":314},"obj":"Gene"},{"id":"794","span":{"begin":380,"end":388},"obj":"Gene"},{"id":"834","span":{"begin":183,"end":191},"obj":"Gene"},{"id":"835","span":{"begin":139,"end":147},"obj":"Gene"},{"id":"836","span":{"begin":94,"end":102},"obj":"Gene"},{"id":"863","span":{"begin":348,"end":351},"obj":"Species"},{"id":"864","span":{"begin":429,"end":448},"obj":"Species"},{"id":"865","span":{"begin":483,"end":491},"obj":"Species"},{"id":"878","span":{"begin":193,"end":197},"obj":"Gene"},{"id":"882","span":{"begin":75,"end":81},"obj":"Gene"}],"attributes":[{"id":"A786","pred":"tao:has_database_id","subj":"786","obj":"Gene:59272"},{"id":"A787","pred":"tao:has_database_id","subj":"787","obj":"Gene:59272"},{"id":"A788","pred":"tao:has_database_id","subj":"788","obj":"Gene:284"},{"id":"A789","pred":"tao:has_database_id","subj":"789","obj":"Gene:59272"},{"id":"A790","pred":"tao:has_database_id","subj":"790","obj":"Gene:305843"},{"id":"A791","pred":"tao:has_database_id","subj":"791","obj":"Gene:24182"},{"id":"A792","pred":"tao:has_database_id","subj":"792","obj":"Gene:305843"},{"id":"A793","pred":"tao:has_database_id","subj":"793","obj":"Gene:116511"},{"id":"A794","pred":"tao:has_database_id","subj":"794","obj":"Gene:305843"},{"id":"A834","pred":"tao:has_database_id","subj":"834","obj":"Gene:305843"},{"id":"A835","pred":"tao:has_database_id","subj":"835","obj":"Gene:284"},{"id":"A836","pred":"tao:has_database_id","subj":"836","obj":"Gene:284"},{"id":"A863","pred":"tao:has_database_id","subj":"863","obj":"Tax:10116"},{"id":"A864","pred":"tao:has_database_id","subj":"864","obj":"Tax:10116"},{"id":"A865","pred":"tao:has_database_id","subj":"865","obj":"Tax:9606"},{"id":"A878","pred":"tao:has_database_id","subj":"878","obj":"Gene:116511"},{"id":"A882","pred":"tao:has_database_id","subj":"882","obj":"Gene:24179"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T254","span":{"begin":237,"end":240},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T255","span":{"begin":298,"end":305},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T256","span":{"begin":393,"end":394},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T257","span":{"begin":395,"end":400},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T258","span":{"begin":395,"end":400},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T259","span":{"begin":395,"end":400},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T260","span":{"begin":395,"end":400},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T261","span":{"begin":401,"end":407},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T262","span":{"begin":408,"end":415},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T263","span":{"begin":473,"end":479},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T137","span":{"begin":6,"end":9},"obj":"Chemical"},{"id":"T138","span":{"begin":75,"end":78},"obj":"Chemical"},{"id":"T139","span":{"begin":79,"end":81},"obj":"Chemical"},{"id":"T140","span":{"begin":83,"end":86},"obj":"Chemical"},{"id":"T141","span":{"begin":94,"end":97},"obj":"Chemical"},{"id":"T142","span":{"begin":127,"end":137},"obj":"Chemical"},{"id":"T143","span":{"begin":139,"end":142},"obj":"Chemical"},{"id":"T144","span":{"begin":183,"end":186},"obj":"Chemical"},{"id":"T145","span":{"begin":202,"end":205},"obj":"Chemical"},{"id":"T146","span":{"begin":227,"end":230},"obj":"Chemical"},{"id":"T147","span":{"begin":279,"end":305},"obj":"Chemical"},{"id":"T148","span":{"begin":298,"end":305},"obj":"Chemical"},{"id":"T149","span":{"begin":380,"end":383},"obj":"Chemical"},{"id":"T150","span":{"begin":408,"end":415},"obj":"Chemical"}],"attributes":[{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A145","pred":"chebi_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A146","pred":"chebi_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_80233"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A149","pred":"chebi_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A150","pred":"chebi_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T30","span":{"begin":266,"end":275},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"LitCovid-sentences","denotations":[{"id":"T100","span":{"begin":165,"end":450},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}

{"project":"2_test","denotations":[{"id":"32708755-27660028-20678716","span":{"begin":359,"end":361},"obj":"27660028"}],"text":"duct, Ang I, to ACE and ACE2, which, together, can produce high amounts of Ang II, Ang (1–9), Ang (1–7) and its (ACE-produced) metabolite, Ang (1–5) (see Figure 1). Similarly to both Ang (1–7)/MasR and Ang (1–9)/AT2R pathways, Ang (1–5) has been shown to induce the secretion of atrial natriuretic peptide via MasR/NOS pathway in isolated perfused rat atria [65], indicating that Ang (1–5) is a heart active peptide (at least in Sprague-Dawley rats). Interestingly, in the plasma of patients with inflammatory"}