-sACE2 complexes bearing enzymatic active sACE2 (see Figure later in the Section 4). Of note, SARS-CoV-2-sACE2 complexes, sequestrating sACE2, can drive part of the sACE2 systemic activity and concentrate it locally where the organs possess cells expressing ACE2 on their surface membrane, i.e., following the viral tropism (see Figure later in the Section 4). Indeed, although the viral load in sputum of adult SARS-CoV patients