Acknowledgments I have to thank Josè Enrique O’Connor, Kishore Wary, Claudio Sorio, Nadir Mario Maraldi, Patrizia Pignatti, John Byrnes, Reza Abdi, Genny del Zotto, Gregary Marhefka, Claudio Ortolani, Renato Zambello, Claudio Pioli, Rita Monticelli, Alessandro Minelli, Piero Sestili, Moreno Zamai and Giuliana Benvenuti for their support and encouragement. Time was precious, as the virus works 24 h a day and 7 days a week. I really hoped that the scientific efforts could become decisive in order to face this dramatic situation and to save people as early and as much as possible but it was not possible. With my work, I hope to reach the future generations and tell them that we cannot play with human health. I would also like to apologize to those whose relevant contributions could not be cited because of my limits.