Pairwise correlations between variables were calculated and visualized as a correlogram using R function corrplot. Spearman's Rank Correlation coefficient (ρ) was indicated by square size and heat scale; significance indicated by: *p < 0.05, **p < 0.01, and ***p < 0.001; black box indicates FDR < 0.05. Heatmaps were created to visualize variable values using R function pheatmap or complexheatmap.