Indeed, convalescent plasma containing neutralizing antibodies can improve clinical symptoms (30). However, not all patients that recover from COVID-19 have detectable neutralizing antibodies (6, 26), suggesting a complex relationship between humoral and cellular response in COVID-19 pathogenesis.
Taken together, this previous work provokes questions about the potential diversity of immune responses to SARS-CoV2 and the relationship of this immune response diversity to clinical disease. However, many studies describe small cohorts or even single patients, limiting a comprehensive interrogation of this diversity. The