Most patients seroconvert within 7-14 days of infection and increased plasmablasts (PB) have been reported (16, 21–23). However, the role of humoral responses in the pathogenesis of COVID-19 remains unclear. Whereas IgG levels reportedly drop slightly ~8 weeks after symptom onset (24, 25), recovered patients maintain high Spike-specific IgG titers (6, 26). IgA levels also can remain high and may correlate with disease severity (25, 27). Furthermore, neutralizing antibodies can control SARS-CoV2 infection in vitro and in vivo (4, 28, 29). Indeed, convalescent plasma containing neutralizing antibodies can improve clinical symptoms (30). However, not all patients that recover from COVID-19 have detectable neutralizing antibodies (6, 26), suggesting a complex relationship between humoral and cellular response in COVID-19 pathogenesis.