PMC:7402624 / 12931-13564 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T72","span":{"begin":168,"end":173},"obj":"Body_part"},{"id":"T73","span":{"begin":191,"end":195},"obj":"Body_part"},{"id":"T74","span":{"begin":332,"end":337},"obj":"Body_part"},{"id":"T75","span":{"begin":431,"end":436},"obj":"Body_part"},{"id":"T76","span":{"begin":568,"end":572},"obj":"Body_part"}],"attributes":[{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-PubTator","denotations":[{"id":"380","span":{"begin":12,"end":16},"obj":"Gene"},{"id":"381","span":{"begin":17,"end":21},"obj":"Gene"},{"id":"382","span":{"begin":54,"end":58},"obj":"Gene"},{"id":"383","span":{"begin":59,"end":63},"obj":"Gene"},{"id":"384","span":{"begin":79,"end":83},"obj":"Gene"},{"id":"385","span":{"begin":84,"end":88},"obj":"Gene"},{"id":"386","span":{"begin":104,"end":108},"obj":"Gene"},{"id":"387","span":{"begin":109,"end":113},"obj":"Gene"},{"id":"388","span":{"begin":140,"end":144},"obj":"Gene"},{"id":"389","span":{"begin":145,"end":149},"obj":"Gene"},{"id":"390","span":{"begin":162,"end":165},"obj":"Gene"},{"id":"391","span":{"begin":185,"end":188},"obj":"Gene"},{"id":"392","span":{"begin":326,"end":330},"obj":"Gene"},{"id":"393","span":{"begin":425,"end":429},"obj":"Gene"},{"id":"394","span":{"begin":468,"end":471},"obj":"Gene"},{"id":"395","span":{"begin":562,"end":565},"obj":"Gene"},{"id":"398","span":{"begin":364,"end":372},"obj":"Species"},{"id":"407","span":{"begin":355,"end":363},"obj":"Disease"},{"id":"408","span":{"begin":385,"end":387},"obj":"Disease"},{"id":"409","span":{"begin":623,"end":625},"obj":"Disease"}],"attributes":[{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Gene:939"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"Gene:1236"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"Gene:939"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"Gene:1236"},{"id":"A384","pred":"tao:has_database_id","subj":"384","obj":"Gene:939"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"Gene:1236"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"Gene:939"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"Gene:1236"},{"id":"A388","pred":"tao:has_database_id","subj":"388","obj":"Gene:939"},{"id":"A389","pred":"tao:has_database_id","subj":"389","obj":"Gene:1236"},{"id":"A390","pred":"tao:has_database_id","subj":"390","obj":"Gene:925"},{"id":"A391","pred":"tao:has_database_id","subj":"391","obj":"Gene:925"},{"id":"A392","pred":"tao:has_database_id","subj":"392","obj":"Gene:953"},{"id":"A393","pred":"tao:has_database_id","subj":"393","obj":"Gene:100513601"},{"id":"A394","pred":"tao:has_database_id","subj":"394","obj":"Gene:925"},{"id":"A395","pred":"tao:has_database_id","subj":"395","obj":"Gene:925"},{"id":"A398","pred":"tao:has_database_id","subj":"398","obj":"Tax:9606"},{"id":"A407","pred":"tao:has_database_id","subj":"407","obj":"MESH:C000657245"},{"id":"A408","pred":"tao:has_database_id","subj":"408","obj":"MESH:D006816"},{"id":"A409","pred":"tao:has_database_id","subj":"409","obj":"MESH:D006816"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T102","span":{"begin":355,"end":363},"obj":"Disease"},{"id":"T103","span":{"begin":385,"end":387},"obj":"Disease"},{"id":"T104","span":{"begin":601,"end":603},"obj":"Disease"},{"id":"T105","span":{"begin":623,"end":625},"obj":"Disease"}],"attributes":[{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0009973"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T162","span":{"begin":5,"end":11},"obj":"http://purl.obolibrary.org/obo/PR_000001015"},{"id":"T163","span":{"begin":12,"end":16},"obj":"http://purl.obolibrary.org/obo/PR_000001963"},{"id":"T164","span":{"begin":17,"end":21},"obj":"http://purl.obolibrary.org/obo/PR_000001203"},{"id":"T165","span":{"begin":47,"end":53},"obj":"http://purl.obolibrary.org/obo/PR_000001015"},{"id":"T166","span":{"begin":54,"end":58},"obj":"http://purl.obolibrary.org/obo/PR_000001963"},{"id":"T167","span":{"begin":59,"end":63},"obj":"http://purl.obolibrary.org/obo/PR_000001203"},{"id":"T168","span":{"begin":72,"end":78},"obj":"http://purl.obolibrary.org/obo/PR_000001015"},{"id":"T169","span":{"begin":79,"end":83},"obj":"http://purl.obolibrary.org/obo/PR_000001963"},{"id":"T170","span":{"begin":84,"end":88},"obj":"http://purl.obolibrary.org/obo/PR_000001203"},{"id":"T171","span":{"begin":91,"end":94},"obj":"http://purl.obolibrary.org/obo/CLO_0002922"},{"id":"T172","span":{"begin":97,"end":103},"obj":"http://purl.obolibrary.org/obo/PR_000001015"},{"id":"T173","span":{"begin":104,"end":108},"obj":"http://purl.obolibrary.org/obo/PR_000001963"},{"id":"T174","span":{"begin":109,"end":113},"obj":"http://purl.obolibrary.org/obo/PR_000001203"},{"id":"T175","span":{"begin":116,"end":119},"obj":"http://purl.obolibrary.org/obo/CLO_0002923"},{"id":"T176","span":{"begin":133,"end":139},"obj":"http://purl.obolibrary.org/obo/PR_000001015"},{"id":"T177","span":{"begin":140,"end":144},"obj":"http://purl.obolibrary.org/obo/PR_000001963"},{"id":"T178","span":{"begin":145,"end":149},"obj":"http://purl.obolibrary.org/obo/PR_000001203"},{"id":"T179","span":{"begin":162,"end":165},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T180","span":{"begin":166,"end":173},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T181","span":{"begin":185,"end":188},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T182","span":{"begin":189,"end":195},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T183","span":{"begin":238,"end":241},"obj":"http://purl.obolibrary.org/obo/CLO_0002922"},{"id":"T184","span":{"begin":267,"end":268},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T185","span":{"begin":332,"end":337},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T186","span":{"begin":428,"end":436},"obj":"http://purl.obolibrary.org/obo/CLO_0001757"},{"id":"T187","span":{"begin":468,"end":471},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T188","span":{"begin":562,"end":565},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T189","span":{"begin":566,"end":572},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T190","span":{"begin":601,"end":603},"obj":"http://purl.obolibrary.org/obo/CLO_0008770"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T49","span":{"begin":30,"end":38},"obj":"Chemical"},{"id":"T50","span":{"begin":385,"end":387},"obj":"Chemical"},{"id":"T51","span":{"begin":425,"end":427},"obj":"Chemical"},{"id":"T52","span":{"begin":601,"end":603},"obj":"Chemical"},{"id":"T53","span":{"begin":623,"end":625},"obj":"Chemical"}],"attributes":[{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_74756"},{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_73812"},{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T34","span":{"begin":39,"end":45},"obj":"http://purl.obolibrary.org/obo/GO_0007613"},{"id":"T35","span":{"begin":579,"end":585},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":66,"end":69},"obj":"GlycoEpitope"},{"id":"T2","span":{"begin":91,"end":94},"obj":"GlycoEpitope"},{"id":"T3","span":{"begin":238,"end":241},"obj":"GlycoEpitope"},{"id":"T4","span":{"begin":281,"end":284},"obj":"GlycoEpitope"},{"id":"T5","span":{"begin":527,"end":530},"obj":"GlycoEpitope"}],"attributes":[{"id":"A1","pred":"glyco_epitope_db_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/AN0701"},{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/AN0703"},{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/AN0703"},{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/AN0701"},{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/AN0701"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}

{"project":"LitCovid-sentences","denotations":[{"id":"T87","span":{"begin":175,"end":295},"obj":"Sentence"},{"id":"T88","span":{"begin":296,"end":398},"obj":"Sentence"},{"id":"T89","span":{"begin":399,"end":542},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells. Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C). Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D). Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A). Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2"}