1) Nasogastric administration can be used in patients unable to take orally because of high fever and coma. The pills can be dissolved in warm but not hot water. The water or decoction used to dissolve the pills should be controlled at 40–60°C. The use of boiling water is forbidden for two reasons: first, to avoid increased decomposition of realgar and cinnabar by high temperature, and reduce generation of the highly toxic arsenic trioxide, free arsenium, and mercury. Research has shown that arsenic trioxide in realgar preparations is not significantly changed below 60°C but begins to increase at 80°C. The decoction used for dissolving AGNHP should therefore not exceed 60°C secondly, musk, borneol and other aromatic substances are volatile. Boiling water could result in excess volatilization, thus, reducing efficacy. 2) Must not be used with nitrate, nitrite, ferrite or sulfate drugs. 3) Not for use in pregnant women. 4) It contains cinnabar and realgar, and should not be taken at high doses for long periods. Should be used with caution in those with hepatic and renal dysfunction. (5) It contains musk, so athletes should use with caution.