Relevant Information on the Clinical Application of AGNHP Recommended Therapeutic Regimens AGNHP has been recommended in 21 therapeutic regimens of COVID-19 in China (see detailed information in Tables 1 and 2 ). Ingredients of AGNHP Curcuma kwangsiensis S.G.Lee & C.F.Liang (Yujin), Calculus Bovis (Niuhuang), Cornu Bubali (Shuiniujiao), Coptis chinensis Franch. (Huanglian), Cinnabaris (Zhusha), Moschus (Shexiang), Margarita (Zhenzhu), Realgar (Xionghuang), Scutellaria baicalensis Georgi (Huangqin), Gardenia jasminoides J.Ellis (Zhizi), and Cinnamomum camphora (L.) J.Presl (Bingpian). Basic information on AGNHP is provided in the Supplementary Table . Indications for the Treatment of COVID-19 With AGNHP AGNHP is used for the syndrome of epidemic toxin lung closure and inner blocking causing collapse in the progressive stage of COVID-19 (critical case). Indicative symptoms are hyper-pyretic convulsions, coma and delirium, difficulty breathing, and dysphoria. Progress of Pharmacological Research on AGNHP Modern pharmacological studies have shown that AGNHP has antipyretic, analgesic, anti-inflammatory, and neuroprotective effects (see Table 3 ). Zuguang Ye et al. discovered that AGNHP could significantly reduce the body temperature of hyperpyrexic rabbits in a fever model induced by intravenous injection of typhoid Vi polysaccharide vaccine in rabbit ear (Ye et al., 2003). Feng Zhang, Kunjie Zhu et al. found in an LPS-induced intracerebral inflammation model that AGNHP antagonized the toxic effect of LPS on dopaminergic neurons, inhibited release of superoxide radical, and reverse changes in cortical monoamine neurotransmitters. It was speculated that its impact on cortical monoamine neurotransmitters might be one of the mechanisms by which AGNHP promoted consciousness in LPS brain damage (Zhang F. et al., 2010; Zhu and Sun, 2014). Research by Dan Zhang et al. showed that AGNHP lowered serum LPS and lung myeloperoxidase (MPO) levels in a rat model of sepsis (Zhang et al., 2009). Yishan Tang et al. found that AGNHP lowered total LDH activity in serum and brain tissue, and changed the percentage of isomerase in a rat pertussis-induced infectious cerebral edema model (Tang et al., 2005). Fan Q et al. discovered that AGNHP had anti-atherosclerotic effects in the high fat diet-induced ApoE−/− mouse model at early- and mid-stage via regulation of Th17/Treg balance. It inhibited chronic inflammation, reduced plaque collagen fibers, and reduced inflammatory cell infiltration (Fan et al., 2020). Clinical Research on AGNHP Modern clinical studies have shown that AGNHP has therapeutic effects against hyperpyrexia, coma caused by severe infectious diseases, and viral encephalitis and severe pneumonia of infants (see Table 3 ). Yueming Feng et al. conducted a systematic evaluation and found that AGNHP could be used to promote consciousness of coma patients with acute cerebral infarction (ACI) and improve neurologic function. This may be due to the ability of AGNHP to alleviate the inflammatory response, reduce cerebral edema, and promote recovery of neurologic function (Feng and Yang, 2015). Haijun Zhang et al. discovered through clinical observation that AGNHP could be used to treat viral encephalitis in children. AGNHP rapidly reduced body temperature, prevented convulsions, promoted consciousness, and alleviated cerebral edema and brain cell damage (Zhang and Dong, 2014). Research by Zhulin Zhuo et al. found that AGNHP with the adjuvant, Ribavirin was efficacious in acute severe viral pneumonia of children, significantly reduced PCT and improved immune function (Zhuo and Wen, 2017). Yanling Shi discovered through clinical observation that AGNHP in combination with sodium phosphate improved anoxic conditions and myocardial damage in patients with neonatal asphyxia and myocardial damage (Shi, 2019). Xie Long et al. in a study of 70 patients with ACI and central hyperpyrexia found that combined use of conventional Western medicine and AGNHP reduced the duration of fever and significantly improved the prognosis (Long and Wu, 2014). Hanwei Liu et al. conducted a systematic review of relevant literature on AGNHP treatment of ACI and cerebral hemorrhage. The results showed that adjuvant treatment with ANP (AGNHP) appeared to improve the total response rate and neurologic deficit score in patients with ACI and acute intracerebral hemorrhage (AIH) (Han et al., 2019). Research by Ma et al. showed that ANP had a moderating effect on Th1/Th2 in cerebral infarction patients (Ma and Zhou, 2015). Usage and Dosage of AGNHP Oral administration. 3 g, once a day. Adverse Reactions of AGNHP Overdose administration might cause mercurial nephrosis or allergic reaction and other adverse reactions. Improper use of this product might cause hypothermia. AGNHP Precautions 1) Nasogastric administration can be used in patients unable to take orally because of high fever and coma. The pills can be dissolved in warm but not hot water. The water or decoction used to dissolve the pills should be controlled at 40–60°C. The use of boiling water is forbidden for two reasons: first, to avoid increased decomposition of realgar and cinnabar by high temperature, and reduce generation of the highly toxic arsenic trioxide, free arsenium, and mercury. Research has shown that arsenic trioxide in realgar preparations is not significantly changed below 60°C but begins to increase at 80°C. The decoction used for dissolving AGNHP should therefore not exceed 60°C secondly, musk, borneol and other aromatic substances are volatile. Boiling water could result in excess volatilization, thus, reducing efficacy. 2) Must not be used with nitrate, nitrite, ferrite or sulfate drugs. 3) Not for use in pregnant women. 4) It contains cinnabar and realgar, and should not be taken at high doses for long periods. Should be used with caution in those with hepatic and renal dysfunction. (5) It contains musk, so athletes should use with caution.